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Case Report Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma
Allison Kaye L. Pagariganorcid , Paulo Giovanni L. Mendozaorcid

DOI: [Epub ahead of print]
Published online: March 13, 2023
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Department of Pathology and Laboratory Medicine, National Kidney and Transplant Institute, Quezon City, Philippines
Corresponding author:  Allison Kaye L. Pagarigan, Tel: +63-2-8981-0300, Fax: +63-2-8981-0300, 
Received: 9 January 2023   • Revised: 23 February 2023   • Accepted: 24 February 2023

Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatric cases reported in literature. Recounted is a case of a 49-year-old female who presented with acute right upper quadrant abdominal pain, elevated serum alpha fetoprotein and a large liver mass on imaging. Hepatectomy was performed under clinical suspicion of hepatocellular carcinoma. Immunomorphologic characteristics of the tumor proved consistent with hepatoblastoma of mixed epithelial and mesenchymal type. Hepatocellular carcinoma remains to be the primary differential diagnosis for adult hepatoblastoma, however, distinguishing between these two neoplasms requires close histomorphologic assessment and immunohistochemical profiling as clinical, radiologic and gross pathologic findings typically overlap. Making this distinction is highly crucial in the timely initiation of surgical and chemotherapeutic interventions for this inherently aggressive and rapidly fatal disease.

JLC : Journal of Liver Cancer