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Journal of the Korean Liver Cancer Study Group 2012;12(2):151-154.
Published online September 30, 2012.
A Case of Refractory Hepatocellular Carcinoma Presented with Brain Metastasis
Eui Bae Kim1, Soung Won Jeong1, Jae Young Jang1, Sae Hwan Lee1, Sang Gyune Kim1, Young Seok Kim1, Hong Soo Kim1, Boo Sung Kim1, A ram Jang2
1Institute for Digestive Research, Departments of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea
2Departments of Radiation Oncology, Soonchunhyang University Hospital, Seoul, Korea
Correspondence:  Soung Won Jeong,
Email: eongsw@schmc.ac.kr
Abstract
Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide and the third leading cause of tumor mortality. The majority of tumors are diagnosed when advanced and then a 5-year survival rate of HCC is below 5%. However, recent progress in the diagnosis and treatment of HCC has made it possible for the patient to survive longer, and as a result, distant metastasis from HCC has increased and attracted more attention than before. HCC can be metastasized to all organs through blood and lymphatic channel. Of the various metastatic sites, the most common site is the lungs, followed by the lymph nodes, musculoskeletal, adrenal and omentum. Also, spleen, small bowel, large bowel and esophagus can be invloved. Brain metastasis can be occurred rarely, and then it is regarded to oncologic emergency. We report a patient who present with brain metastasis of progressing HCC despite of treatment.
Key Words: Hepatocellular carcinoma; Brain metastasis
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