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HOME > J Liver Cancer > Volume 17(2); 2017 > Article
Review Article Non-alcoholic Fatty Liver Disease and Hepatocellular Carcinoma
Hyunwoo Oh1,2, Dea Won Jun1
Journal of Liver Cancer 2017;17(2):117-125
DOI: https://doi.org/10.17998/jlc.17.2.117
Published online: September 30, 2017
1Department of Internal Medicine, Hanyang University College of Medicine, Seoul
2Korean Armed Forces Cheongpyeong Hospital, Gapyeong, Korea
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Hepatocellular carcinoma (HCC) is one of the most common life-threatening cancers worldwide. Recently, many patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have progressed to HCC even in the absence of cirrhosis. As the morbidity of metabolic syndrome increases, the proportion of HCC associated with NAFLD is expected to increase gradually. A new mechanism for the development of HCC in NAFLD has been identified; Diabetes mellitus, insulin resistance, obesity, lipotoxicity, gut dysbiosis are risk factors. Inflammatory cytokines such as adipokines, leptin, tumor necrosis factor-α, interlukin-8, nuclear factor-κB constitute dysplasia-carcinoma sequence. At the time of diagnosis, NAFLD/ NASH related HCC tend to progress to larger and in advanced tumor-node-metastasis stages compared to viral hepatitis related HCC. But there are no guidelines for early detection of NAFLD-related HCC. So, it is essential to study the screening program for the early detection of NAFLD-related HCC and precise methods for NAFLD.


JLC : Journal of Liver Cancer