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HOME > J Liver Cancer > Volume 10(1); 2010 > Article
Case Report A Case of Advanced Hepatocellular Carcinoma Presenting as Skull Metastasis
Nae-Yun Heo, Han Chu Lee, Ju Hyun Shim, Young-Suk Lim, Young-Hwa Chung, Yung Sang Lee, Dong Jin Suh
Journal of Liver Cancer 2010;10(1):73-75
DOI: https://doi.org/
Published online: June 30, 2010
Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Corresponding author:  Han Chu Lee,
Email: hch@amc.seoul.kr
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Hepatocellular carcinoma is known to spread to distant organ via hematogenous or osseous route in about 15% of the patients during its clinical course. However, it is rare that the distant metastatic symptom and sign are the diagnostic clues to find the primary hepatocellular carcinoma, because most of the patients are likely to expire due to rapid disease progression before the presentation of the clinical findings of metastasis. Detection of early hepatocelluar carcinoma through surveillance of the high risk population will reduce the chance of initial presentation of metastatic symptom. In spite of this trend, we experienced a case of hepatocellular carcinoma presenting as skull metastasis at diagnosis, which suggests that some patients still complain of metastatic symptom as initial presentation of hepatocellular carcinoma.


JLC : Journal of Liver Cancer