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Journal of the Korean Liver Cancer Study 2009;9(1):45-48.
Published online June 30, 2009.
Rapid recurrence following living donor liver transplantation for hepatocellular carcinoma within Milan criteria
Hyun Young Woo1, Jin Dong Kim2, Jung Hyun Kwon2, Si Hyun Bae2, Jong Young Choi2, Seung Kew Yoon2, Sung Eun Rha3, Jae Young Byun3, Ho Jong Chun3, Byung Gil Choi3, Hae Kyu Lee3, Young Kyoung You4, Dong Gu Kim4
1Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea
2Department of Internal Medicine, Seoul St. Mary’ Hospital,College of Medicine, The Catholic University of Korea
3Department of Radiology, Seoul St. Mary’ Hospital,College of Medicine, The Catholic University of Korea
4Department of Surgery, Seoul St. Mary’ Hospital,College of Medicine, The Catholic University of Korea
Correspondence:  Jong Young Choi,
Email: jychoi@catholic.ac.kr
Copyright ©2009 by The Korean Liver Cancer Association
Abstract
Liver transplantation is curative therapy for hepatocellular carcinoma especially if ,within Milan criteria, 4 year survival and recurrence-free survival was reported to be 85% and 92%, respectively. Herein we report a patient who experience rapid recurrence following living donor liver transplantation (LDLT) for hepatocellular carcinoma within Milan criteria. A 52 year-old-men patient with known liver cirrhosis associated with hepatitis B virus was admitted for the treatment of hepatocellular carcinoma (HCC). Abdominal CT revealed two nodules less than 3 cm in right hepatic lobe. After single session of transcatheter arterial chemoembolization (TACE), the patient underwent LDLT. After seven months following transplantation, recurrent HCC was detected on transplanted liver with concurrent metastatic nodule in lung. Although TACE and metastsectomy were performed for recurrent intrahepatic mass and lung metastasis, recurrent HCC showed rapid progression and patient died of progressive tumor after 10 months following LDLT.
Key Words: Hepatocellular carcinoma; Recurrence; Liver transplantation; Milan criteria
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