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J Liver Cancer > Volume 16(2); 2016 > Article
Journal of Liver Cancer 2016;16(2):123-128.
DOI: https://doi.org/10.17998/jlc.16.2.123    Published online September 30, 2016.
A Case of Achieving Complete Remission with Stereotactic Body Radiation Therapy in Patients with Hepatocellular Carcinoma with Macrovascular Invasion after Repeated Transarerial Chemoembolization
Sang Youn Hwang1, Seon-Mi Lee1, Jong Woo Im1, Ki Jeong Jeon1, Sang Bu Ahn2, Eun Kyeong Ji2, Jin-Young Park2, Cheol-Won Choi Choi3, Gwang-Mo Yang3
1Departments of Internal Medicine, Dongnam Institute of Radiological and Medical Sciences,Busan, Korea
2Departments of Radiology, Dongnam Institute of Radiological and Medical Sciences,Busan, Korea
3Departments of Radiation Oncology, Dongnam Institute of Radiological and Medical Sciences,Busan, Korea
Correspondence:  Sang Youn Hwang,
Email: mongmani@hanmail.net
Abstract
Transarterial chemoembolization (TACE) is the worldwide procedure performed for patients with various stage hepatoceullar carcinoma (HCC), but is not yet considered as curative treatment because of relatively high local recurrence rate. Moreover, many clinicians frequently experience treatment failure (incomplete necrosis or stage progression etc.) after repeated TACE, but no clear guidelines have been recommended about salvage treatment modalities for this situation. Recently, studies for combination of radiation therapy and TACE for HCC with TACE refractoriness have been tried and reported better therapeutic efficacy. Based on above suggestions, we herein offer our experience of a patient with macrovascular invasion developed after repeated TACE that achieve complete remission by stereotactic body radiation therapy. Further study, maybe regarding a combination of locoregional and systemic therapy, is necessary on how to manage HCC patients with TACE refractoriness.
Key Words: Hepatocellular carcinoma; Transarterial chemoembolization (TACE) refractory; Stereotactic body radiation therapy
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