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Journal of the Korean Liver Cancer Study 2007;7(1):87-93.
Published online June 30, 2007.
Effect of combination therapy with TACE and 3D-CRT for two patients with PVT and/or IVC tumor thrombus
Hyun Deok Shin, Young-Suk Lim, Soon Joo Kim, Sang Hyun Park, Gang Mo Kim, Han Chu Lee, Young Hwa Jung, Young Sang Lee, Dong Jin Suh
Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
Correspondence:  Hyun Deok Shin,
Email: emedicals@hanmail.net
Copyright ©2007 by The Korean Liver Cancer Association
Advanced hepatocellular carcinoma has a poor prognosis, especially in the cases with portal vein or IVC tumor thrombi. In such cases, surgical resection could not be a curative treatment option and transcatheter arterial chemoembolization (TACE) alone is usually ineffective. Recently, three-dimensional conformal radiation therapy (3D-CRT) has been developed to better conform the radiation dose to the tumor volume in order to reach the goal of eradicating local disease without injuring normal tissue. Combination therapy with TACE and 3D-CRT could be considered as a treatment option for advanced HCC with PV or IVC tumor thrombi. We report here two cases with advanced HCC showing response to combination therapy with repeated TACE and 3D-CRT.
Key Words: Hepatocellular carcinoma; Transcatheter arterial chemoembolization; Three-dimensional conformal radiation therapy; Tumor thrombi
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