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HOME > J Liver Cancer > Volume 4(1); 2004 > Article
Case Report Poorly-differentiated Carcinoma in Well-differentiated Hepatocellular Carcinoma (Nodule-in-nodule) and Concurrent Moderately-differentiated Hepatocellular Carcinoma: A Case Report
Sang Kyun Yu1, Soon Ho Um1, Yoon Hwan Kim2, Nam Hee Won3
Journal of Liver Cancer 2004;4(1):46-49
DOI: https://doi.org/
Published online: June 30, 2004
1Department of Internal Medicine, Korea University College of Medicine Anam Hospital, Seoul, Korea
2Department of Radiology, Korea University College of Medicine Anam Hospital, Seoul, Korea
3Department of Pathology, Korea University College of Medicine Anam Hospital, Seoul, Korea
Corresponding author:  Soon Ho Um,
Email: umsh@korea.ac.kr
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Extensive studies on early stage hepatocellular carcinomas (HCCs) have defined its pathomorphologic features. Most early HCCs are well-differentiated and an ill-defined nodular appearance. Proliferation of well-differentiated, small HCCs is closely related to tumor size of 1.0-1.5 cm in diameter. Furthermore, less differentiated cancerous tissues with greater proliferative activity can evolve within ti. Such a phenomenon is often appreciated grossly and/or histologically, and is called as a "nodule in nodule" appearance. We report a case of poorly-differentiated carcinoma in well-differentiated hepatocellular carcinoma (nodule-in-nodule) and concurrent moderatedly-differentiated hepatocellular carcinoma.

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