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Journal of the Korean Liver Cancer Study 2011;11(2):97-103.
Published online September 30, 2011.
Toll-like Receptors and Carcinogenesis
Geum-Youn Gwak
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Correspondence:  Geum-Youn Gwak,
Email: gy.gwak@samsung.com
Copyright ©2011 by The Korean Liver Cancer Association
Abstract
Toll-like receptors are a family of pattern recognition receptors that allow the immune system to sense molecules that are present in most classes of pathogens such as bacteria and viruses, but not the host, and to coordinate defense mechanisms against these pathogens. Emerging evidence also suggests that TLRs have an important role in maintaining tissue homeostasis by regulating the inflammatory and tissue repair responses to injury. Due to the important role in inflammation, tissue regeneration and fibrogenesis, TLRs are potential candidates to mediate effects of the innate immune system on carcinogenesis. Although the role of TLRs in carcinogenesis is far from being completely understood, current data suggest a dual role of TLRs in carcinogenesis: anti-tumor effects versus tumor-promoting effects. Here we discuss how TLRs function in the context of carcinogenesis.
Key Words: Toll-like receptor; Carcinogenesis
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