Hepatocelluar carcinoma (HCC) is one of the cancers with poor prognosis as HCC develops on base of cirrhosis in majority cases, which requires multidisciplinary approach. Hepatic arterial infusion chemotherapy (HAIC) allows for relatively easy replenishment of administering agents into the hepatic artery and achieves higher intrahepatic concentrations. We report a case of multiple HCC with decompensated liver cirrhosis treated by HAIC.