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Journal of the Korean Liver Cancer Study 2007;7(1):62-65.
Published online June 30, 2007.
A Case of Combined hepatocellular carcinoma and cholangiocarcinoma (CHC) without underlying liver disease.
Jae Hoon Jung1, Jung Il Kim1, Sun Hyung Kang1, Seok Hee Moon1, Seok Hyun Kim1, Byung Seok Lee1, Heon Young Lee1, Joon Sik Cho2, Kyung Sook Shin2, Dae Young Kang3, Hyun Mo Kang4
1Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea
2Department of Radiology, Chungnam National University College of Medicine, Daejeon, Korea
3Department of Pathology, Chungnam National University College of Medicine, Daejeon, Korea
4The sun hospital, Daejeon, Korea
Correspondence:  Seok Hyun Kim,
Email: midoctor@cnuh.co.kr
Copyright ©2007 by The Korean Liver Cancer Association
Abstract
Combined hepatocellular carcinoma and cholangiocarcinoma (CHC) is a rare form of primary liver cancer having features of both hepatocelluar and biliary epithelial differentiation and is related to cirrhosis. Recently, a 64-oldmale who was admitted to our hospital for evaulation of hepatic mass which was detected on ultrasonography. He had no underlying cirrhosis. Based on serologic findings of high alpha-fetoprotein(AFP) level, a preoperative diagnosis of hepatocellular carcinoma was made. A right lobectomy was done. On histologic examination, the resected tumor was shown to consist of two different tissues. On immunohistochemistry, the tumor is postitive for both anti-hepatocyte, CK-7 and CK-19. Finally we confirm combined hepatocellular carcinoma and cholangiocarcinoma (CHC).
Key Words: Combined hepatocellular carcinoma and cholangiocarcinoma; Alpha fetoprotein (AFP)
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