Journal of Liver Cancer

Review Articles

Imaging prognostication and tumor biology in hepatocellular carcinoma: Diana Kadi, Marilyn F. Yamamoto, Emily C. Lerner, Hanyu Jiang, Kathryn J. Fowler, Mustafa R. Bashir; J Liver Cancer. 2023;23(2):284-299. Published online September 15, 2023; DOI: https://doi.org/10.17998/jlc.2023.08.29

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Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, and represents a significant global health burden with rising incidence rates, despite a more thorough understanding of the etiology and biology of HCC, as well as advancements in diagnosis and treatment modalities. According to emerging evidence, imaging features related to tumor aggressiveness can offer relevant prognostic information, hence validation of imaging prognostic features may allow for better noninvasive outcomes prediction and inform the selection of tailored therapies, ultimately improving survival outcomes for patients with HCC.

Citations

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Hyperenhancement of pituitary neuroendocrine tumors (PitNETs) on preoperative MRI: implications on tumor characteristics and outcomes
Philip E. Shih, Robert C. Osorio, Lynn Leng, Blanca Morales Lugo, Shiv Gupta, Lewis Blevins Jr., Philip Theodosopoulos, Jose Gurrola, Ivan H. El Sayed, Sandeep Kunwar, Javier Villanueva-Meyer, Manish K. Aghi
Journal of Clinical Neuroscience.2026; 143: 111747. CrossRef
Membranous Overexpression of Fibronectin Predicts Microvascular Invasion and Poor Survival Outcomes in Patients with Hepatocellular Carcinoma
Yoon Jung Hwang, Hyejung Lee, Suk Kyun Hong, Su Jong Yu, Haeryoung Kim
Gut and Liver.2025; 19(2): 275. CrossRef
MRI Imaging Biomarkers for Prognostication of Hepatocellular Carcinoma
Ja Kyung Yoon, Jin-Young Choi
Journal of the Korean Society of Radiology.2025; 86(3): 364. CrossRef
Role of imaging-guided biopsy for hepatocellular carcinoma
Roberto Cannella, Zachary T. Berman, Nikhil V. Tirukkovalur, Samer T. Tohme, Marta I. Minervini, Alessandro Furlan
European Journal of Radiology.2025; 191: 112271. CrossRef
Prognostic and predictive imaging markers of hepatocellular carcinoma: a pictorial essay
Claudia Deyirmendjian, Banmeet Padda, Kathryn J. Fowler, Victoria Chernyak, Claude B. Sirlin, Hanyu Jiang, Kim-Nhien Vu, Joseph R. Dadour, Jessica Murphy-Lavallée, Jean-Sébastien Billiard, Damien Olivié, Bich N. Nguyen, An Tang
Insights into Imaging.2025;[Epub] CrossRef
Peritumoral bone changes in mandibular gingival squamous cell carcinoma: A prospective radiologic-histopathologic correlation study
Gyu-Dong Jo, Kyu-Young Oh, Jo-Eun Kim, Won-Jin Yi, Min-Suk Heo, Sam-Sun Lee, Kyung-Hoe Huh
Journal of Dental Sciences.2025;[Epub] CrossRef
Case 339: Hepatobiliary Contrast Agent Uptake in an Adrenal Metastasis from Hepatocellular Carcinoma
Benjamin Rea, Anthony Blakeborough
Radiology.2025;[Epub] CrossRef
Improving surgical treatments for hepatocellular carcinoma
Abdullah K. Malik, Daniel Geh, Thomas R. Jeffry Evans, Pierce K. H. Chow, Derek A. Mann, Steven A. White
Nature Reviews Gastroenterology & Hepatology.2025;[Epub] CrossRef

Recent updates on the classification of hepatoblastoma according to the International Pediatric Liver Tumors Consensus: Se Un Jeong, Hyo Jeong Kang; J Liver Cancer. 2022;22(1):23-29. Published online March 17, 2022; DOI: https://doi.org/10.17998/jlc.2022.02.24

14,548 Views
814 Downloads
11 Citations

Abstract PDF

Hepatoblastoma is the most common pediatric liver malignancy and usually occurs within the first 3 years of life. In recent years, the overall incidence of hepatoblastoma has exhibited the greatest increase among all pediatric malignancies worldwide. The diagnosis of hepatoblastoma may be challenging due to the lack of a current consensus classification system. The International Pediatric Liver Tumors Consensus introduced guidelines and a consensus classification for the diagnosis of hepatoblastoma as either epithelial or mixed epithelial and mesenchymal and in the updated 5^th edition of the World Health Organization Classification of Digestive System Tumors.

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MRI major and ancillary features of LI-RADS for diagnosis of pediatric malignant liver tumors
Se Jin Choi, Jeong In Shin, Pyeong Hwa Kim, Hyo Jung Park, Seonok Kim, Ah Young Jung, Young Ah Cho, Jin Seong Lee, In Hye Song, Sujin Gang, Jung-Man Namgoong, Kyung-Nam Koh, Hee Mang Yoon
European Radiology.2025; 35(12): 7688. CrossRef
Efficient derivation of immortalized, isogenic cell lines from genetically defined murine hepatoblastomas
Huabo Wang, Jie Lu, Keyao Chen, Bingwei Ma, Colin Henchy, Jessica Knapp, Sarangarajan Ranganathan, Edward V. Prochownik
Biochemical and Biophysical Research Communications.2025; 780: 152478. CrossRef
Global trends and regional differences of hepatoblastoma: a systematic analysis and predictions to 2035 based on the global burden of disease study 2021
Kai Shi, Congcong Xu, Xueyao Zhang, Hao Liang, Xiaohui Li, Bo Liu, Qingliang Wang
BMC Public Health.2025;[Epub] CrossRef
Identification of CD7 as a novel biomarker of embryonal hepatoblastoma
Ahmad Adawy, Daiki Yoshii, Hiroki Hirao, Yoshihiro Komohara, Yukio Fujiwara, Masahiro Tomita, Masaki Honda, Jia Han, Yao Liu, Sohsuke Yamada, Masahiro Yamamoto, Eiso Hiyama, Taizo Hibi
Pediatric Surgery International.2025;[Epub] CrossRef
Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang
Advanced Science.2025;[Epub] CrossRef
Tumor‐associated macrophages: The key player in hepatoblastoma microenvironment and the promising therapeutic target
Ahmad Adawy, Yoshihiro Komohara, Taizo Hibi
Microbiology and Immunology.2024; 68(8): 249. CrossRef
Hepatoblastoma: A Case Report
Abel Ning Caballero, Kandecy Archer-Austin
Asploro Journal of Biomedical and Clinical Case Reports.2024; 7(3): 226. CrossRef
Adult Hepatoblastoma and Concomitant Hepatitis B Infection
Alejandro Nieto Dominguez, Sarah Elizabeth Eichinger, Elza Matrova, Anas Almoghrabi
ACG Case Reports Journal.2024; 11(9): e01491. CrossRef
Metabolic and Epigenetic Mechanisms in Hepatoblastoma: Insights into Tumor Biology and Therapeutic Targets
Yuanji Fu, Raquel Francés, Claudia Monge, Christophe Desterke, Agnès Marchio, Pascal Pineau, Yunhua Chang-Marchand, Jorge Mata-Garrido
Genes.2024; 15(11): 1358. CrossRef
Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma
Allison Kaye L. Pagarigan, Paulo Giovanni L. Mendoza
Journal of Liver Cancer.2023; 23(1): 219. CrossRef
Advances in Histological and Molecular Classification of Hepatocellular Carcinoma
Joon Hyuk Choi, Swan N. Thung
Biomedicines.2023; 11(9): 2582. CrossRef

Case Report

A Case of Lymphocyte-Rich Hepatocellular Carcinoma in a Patient Who Was Treated for Colon Cancer: Jae Won Song, Ho Soo Chun, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Young Nyun Park, Dai Hoon Han, Do Young Kim; J Liver Cancer. 2021;21(1):69-75. Published online March 31, 2021; DOI: https://doi.org/10.17998/jlc.21.1.69

6,943 Views
100 Downloads
3 Citations

Abstract PDF

Hepatocellular carcinoma (HCC) primarily originates in the liver with hepatic differentiation. However, HCCs are not homogenous, and approximately 35% of HCC cases are classified as histopathological variants that present distinct pathologic characteristics. In particular, the lymphocyte-rich variant is the rarest subtype accounting for less than 1% of HCCs, which is not well known to date about molecular features and pathophysiology. Herein, we present a case of a patient who was suspected of metastatic liver cancer and confirmed as lymphocyte-rich HCC pathologically. A 78-year-old woman who underwent a right hemicolectomy for colon cancer was referred to our hospital for a newly detected liver mass. We could not make a decision because of insufficient evidence for diagnosis from imaging studies. After resection, we found that it was a lymphocyte-rich HCC. The pathologic features and prognostic trends of this subtype are also discussed.

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The Association Between Hepatocellular Carcinoma and Gastrointestinal Adenocarcinoma: Is This a New Syndrome in Patients With Cirrhosis? A Case Series
Fabrizio Bronte, Fabio D'Amato, Maria Rosa Barcellona, Giuseppe Bronte, Giuseppe Malizia, Salvatore Ialuna, Giorgio Fusco, Francesco Verderame, Enrico Bronte, Maria Grazia Bavetta
Cancer Reports.2025;[Epub] CrossRef
Characterization of lymphocyte‐rich hepatocellular carcinoma and the prognostic role of tertiary lymphoid structures
Bokyung Ahn, Hee‐Sung Ahn, Jinho Shin, Eunsung Jun, Eun‐Young Koh, Yeon‐Mi Ryu, Sang‐Yeob Kim, Chang Ohk Sung, Ju Hyun Shim, JeongYeon Hong, Kyunggon Kim, Hyo Jeong Kang
Liver International.2024; 44(5): 1202. CrossRef
Uncommon variants of hepatocellular carcinoma: Not one size fits all
Reetu Kundu, Nalini Gupta, Debajyoti Chatterjee, Ajay Duseja
Diagnostic Cytopathology.2022; 50(1): 28. CrossRef

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