Transarterial chemoembolization (TACE) is one of treatment modalities which can give survival benefit to patients with hepatocellular carcinoma (HCC) to which curative therapies can be applied. But, TACE can encounter the risk of liver failure in case of HCC with main portal vein tumor thrombi. Advances in techniques to account for respiration motion and understanding of partial liver tolerance to radiation therapy have permitted us to deliver high dose radiation therapy without toxicity in treatment of HCC. We report a case of HCC with massive portal vein thrombosis which responded to TACE following radiation therapy.