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HOME > J Liver Cancer > Volume 4(1); 2004 > Article
Case Report Small Hepatocellular Carcinoma in Dysplastic Nodule
Chang Wook Kim1, Eun Sun Jung2, Jong Young Choi1, Jeong Won Jang1, Si Hyun Bae1, Seung Kew Yoon1, Chang Don Lee1, Kyu Won Chung1, Hee Sik Sun1
Journal of Liver Cancer 2004;4(1):50-54
Published online: June 30, 2004
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1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
2Department of Clinicla Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
Corresponding author:  Jong Young Choi,

Dysplastic nodule (DN) is considered as precancerous lesion of hepatocellular carcinoma (HCC). There are several evidences to support the theory about multistep progression of hepatocarcinogenesis. Recently we experienced a patient with HCC of the odule-in-nodule pattern, namely small HCC within DN, which supported the multistep theory of hepatocarcinogenesis. The tumor was seen as a 3 cm, arterial enhancing mass with delayed wash-out patterns in the segment Ⅶ at helical CT. The patient was treated by surgical resection. A 3.0×2.5 cm mass was seen in the resected specimen. A 2.2×1.5 cm, smaller nodule was observed within this mass, i.e. the odule-in-nodule pattern. Microscopically, various grades of HCC foci were seen within high grade DN. Because DN does not always progress to HCC, further studies are needed to evaluate what kind of DN has the high possibility of progressing of HCC at last.

JLC : Journal of Liver Cancer