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Review Article Intrahepatic cholangiocarcinoma; histological diversity and the role of the pathologist
Mina Komutaorcid

DOI: https://doi.org/10.17998/jlc.2023.12.11 [Accepted]
Published online: January 3, 2024
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Department of Pathology, International University of Health and Welfare, School of Medicine, Narita Hospital, Chiba, Japan
Corresponding author:  Mina Komuta, Tel: +81-(0)476-35-5600, Fax: +81-(0)476-35-5737, 
Email: mina.komuta@gmail.com
Received: 31 October 2023   • Revised: 9 December 2023   • Accepted: 11 December 2023

Intrahepatic cholangiocarcinoma (iCCA) is one of the primary liver cancers (PLC) and presents with tumor heterogeneity. About 50% of iCCAs comprise actionable mutations, which completely change patient management. In addition, the precise diagnosis of iCCA, including subtype, has become crucial, and pathologists play an important role in this regard. This review focuses on iCCA heterogeneity; looking at different perspectives to guide diagnosis and optimal treatment choice.

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