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HOME > J Liver Cancer > Volume 18(1); 2018 > Article
Case Report A Case of Management for Advanced Hepatocellular Carcinoma with Extrahepatic Metastasis by Autologous Natural Killer Cells Combined with Immune Checkpoint Inhibitor
Woo, Ara , Kim, Eun Ju , Shin, Sun Young , Jeon, Hong Jae , Park, Hana , Chon, Young Eun , Lee, Yun Bin , Hwang, Seong Gyu , Rim, Kyu Sung , Lee, Joo Ho
Journal of Liver Cancer 2018;18(1):67-74
DOI: https://doi.org/10.17998/jlc.18.1.67
Published online: March 31, 2018
1Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea. ljh0505@cha.ac.kr
2Division of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
3Division of Oncology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
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Hepatocellular carcinoma (HCC) has extremely poor prognosis. Immunotherapy has emerged as a new treatment for a number of cancers. Adoptive immunotherapy is one of the important cancer immunotherapy, which relies on the various lymphocytes including cytotoxic T lymphocytes, natural killer (NK) and cytokine induced killer cells. Also, there has been advance in techniques of NK cell activation to more effectively kill the cancer cells. Of note, recently the blocking antibodies targeting programmed cell death protein 1 (PD-1) have shown promising results in diverse cancers including HCC. We report our recent experience of a patient accompanying advanced HCC with extrahepatic metastases. Disease progression had occurred after sorafenib administration, while the patient showed local tumor control and tumor marker decrease by NK cell immunotherapy combined with PD-1 inhibitor therapy. Though, there was no definite survival advantage due to impaired liver function, which might be caused by treatment related toxicities as well as cancer progression.

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