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HOME > J Liver Cancer > Volume 18(1); 2018 > Article
Review Article Translational Application of Single-cell Transcriptomic Analysis in Hepatocellular Carcinoma
Yoon, Seung Kew
Journal of Liver Cancer 2018;18(1):1-8
Published online: March 31, 2018
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1The Catholic University Liver Research Center & WHO Collaborating Center of Viral Hepatitis, College of Medicine, The Catholic University of Korea, Seoul, Korea.
2Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The emergence of single-cell technology in recent years has made remarkable progress for understanding of biological process in various diseases including cancers. In particular of cancer, single-cell transcriptome analysis provides a powerful tool for comprehensive characterization of cancer cell subpopulations within a heterogeneous bulk populations. Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer and its molecular mechanism is extremely complex associated with a poor prognosis. To date, the molecular mechanisms of hepatocarcinogenesis remain unclear. Here, I review current status of single-cell transcriptome analysis for HCC, focusing on their application for cancer genomics, circulating tumor cells, cancer stem cells and tumor infiltrating cells in HCC.

JLC : Journal of Liver Cancer