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HOME > J Liver Cancer > Volume 18(1); 2018 > Article
Review Article Translational Application of Single-cell Transcriptomic Analysis in Hepatocellular Carcinoma
Yoon, Seung Kew
Journal of Liver Cancer 2018;18(1):1-8
DOI: https://doi.org/10.17998/jlc.18.1.1
Published online: March 31, 2018
1The Catholic University Liver Research Center & WHO Collaborating Center of Viral Hepatitis, College of Medicine, The Catholic University of Korea, Seoul, Korea. yoonsk@catholic.ac.kr
2Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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The emergence of single-cell technology in recent years has made remarkable progress for understanding of biological process in various diseases including cancers. In particular of cancer, single-cell transcriptome analysis provides a powerful tool for comprehensive characterization of cancer cell subpopulations within a heterogeneous bulk populations. Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer and its molecular mechanism is extremely complex associated with a poor prognosis. To date, the molecular mechanisms of hepatocarcinogenesis remain unclear. Here, I review current status of single-cell transcriptome analysis for HCC, focusing on their application for cancer genomics, circulating tumor cells, cancer stem cells and tumor infiltrating cells in HCC.


JLC : Journal of Liver Cancer