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HOME > J Liver Cancer > Volume 17(1); 2017 > Article
Case Report A Case of Hepatocellular Carcinoma with Pulmonary Metastasis Who Showed Complete Response by Cytotoxic Chemotherapy after Sorafenib Failure
Hwa-Sun Park1, Jae Young Jang1, Min Young Baek1, Yong Kwon Kim1, Hyun Jin Youn1, Su Young Back1, Soung Won Jeong1, Sae Hwan Lee2, Sang Gyune Kim3, Sang Woo Cha1, Young Seok Kim3, Young Deok Cho1, Hong Soo Kim2, Boo Sung Kim1
Journal of Liver Cancer 2017;17(1):72-76
DOI: https://doi.org/10.17998/jlc.17.1.72
Published online: March 31, 2017
1Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul
2Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan
3Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine,Bucheon, Korea
Corresponding author:  Jae Young Jang,
Email: jyjang@schmc.ac.kr
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Abstract

Hepatocellular carcinoma (HCC) is the 2nd most common cause of cancer related death in Korea and well-known malignancy with poor prognosis. Sorafenib is the first-line molecular targeted agent in patients with extra-hepatic spread of HCC. However, complete response is extremely rare in patients treated with sorafenib and the disease control rate is only 43%. We report a 53-year-old man with advanced HCC with pulmonary metastasis who showed complete response by cytotoxic chemotherapy with doxorubicin and cisplatin with relatively tolerable adverse effects after failure of treatment with sorafenib.

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