A Case of Surgical Resection in Hepatocellular Carcinoma with Pulmonary Metastasis

Jung, Woo Jin; Jang, Jae Young; Park, Jun Seok; Lee, Hee Jeong; Cho, Young Kyu; Jeong, Soung Won; Lee, Sae Hwan; Kim, Snag Gyune; Cha, Sang Woo; Kim, Young Seok; Cho, Young Deok; Kim, Hong Soo; Kim, Boo Sung

doi:2016.16.2.145

J Liver Cancer > Volume 16(2); 2016 > Article

Case Report

Journal of Liver Cancer 2016;16(2):145-150.
DOI: https://doi.org/10.17998/jlc.16.2.145 Published online September 30, 2016.

A Case of Surgical Resection in Hepatocellular Carcinoma with Pulmonary Metastasis

Woo Jin Jung¹, Jae Young Jang¹, Jun Seok Park¹, Hee Jeong Lee¹, Young Kyu Cho¹, Soung Won Jeong¹, Sae Hwan Lee², Snag Gyune Kim³, Sang Woo Cha¹, Young Seok Kim³, Young Deok Cho¹, Hong Soo Kim², Boo Sung Kim¹

¹Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea
²Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine,Cheonan, Korea
³Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine,Bucheon, Korea

Correspondence: Jae Young Jang,
Email: jyjang@schmc.ac.kr

Abstract

Hepatocellular carcinoma (HCC) is well known malignancy with poor prognosis, even after resection of the primary tumor. Sorafenib is the first-line treatment in advanced HCC, but the disease control rate of sorafenib is only 43%. Pulmonary metastasectomy in patients with pulmonary metastasis from HCC has been reported to increase long-term survival compared with systemic chemotherapy. Video-assisted thoracic surgery is considered a reliable approach to the diagnosis and treatment of pulmonary diseases with low complication rate. Pulmonary metastasectomy is not universally accepted because of frequent local recurrence, an uncontrollable primary tumor, and frequent multiple pulmonary metastases in HCC, but outcome of pulmonary metastasectomy and adjuvant sorafenib therapy has not been studied. We experienced a patient who had advanced HCC with pulmonary oligometastasis and received surgical resection of the metastatic pulmonary nodule and sorafenib chemotherapy. In advanced HCC with pulmonary oligometastasis, surgical resection of pulmonary metastasis and sorafenib chemotherapy should be considered.

Key Words: Hepatocellular carcinoma; Metastasis; Metastasectomy; Sorafenib

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