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HOME > J Liver Cancer > Volume 16(2); 2016 > Article
Case Report Sarcomatoid Intrahepatic Cholangiocarcinoma: A Rare Case of Primary Liver Cancer
Doo Hyuck Lee1, Kyu Hyung Han1, Sun Young Ahn1, Sang Sun Kim1, Hyun Sung Shin1, Ki Bae Bang1, Jun Ho Choi1, Suk Bae Kim1, Won Ae Lee2, il Han Song1
Journal of Liver Cancer 2016;16(2):139-144
DOI: https://doi.org/10.17998/jlc.16.2.139
Published online: September 30, 2016
1Departments of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea
2Departments of Pathology, Dankook University College of Medicine, Cheonan, Korea
Corresponding author:  il Han Song,
Email: ihsong21@dankook.ac.kr
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Sarcomatoid carcinoma arising from intrahepatic cholangiocyte, an extremely rare primary liver cancer, has highly invasive and metastatic potential. The pathogenesis of this tumor is unclear, although histogenetic mechanisms, such as transdifferentiation/dedifferentiation (epithelialmesenchymal transition or metaplastic transformation), biphasic differentiation (combination and collision), and redifferentiation, might be suggested to explain the simultaneous coexistence of carcinoma and sarcoma components in the same tumor. Immunohistochemical staining might be necessary to differentiate whether sarcomatous component is originated from hepatocyte or cholangiocyte. We report a case of sarcomatoid intrahepatic cholangiocarcinoma in a 58 year-old man presenting as an incidentally detected liver mass on regular health examination, which was diagnosed by an application of immunohistochemical methods after surgical resection, with a review of the literature based on 9 cases reported in Korea.


JLC : Journal of Liver Cancer