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J Liver Cancer > Volume 16(2); 2016 > Article
Journal of Liver Cancer 2016;16(2):139-144.
DOI: https://doi.org/10.17998/jlc.16.2.139    Published online September 30, 2016.
Sarcomatoid Intrahepatic Cholangiocarcinoma: A Rare Case of Primary Liver Cancer
Doo Hyuck Lee1, Kyu Hyung Han1, Sun Young Ahn1, Sang Sun Kim1, Hyun Sung Shin1, Ki Bae Bang1, Jun Ho Choi1, Suk Bae Kim1, Won Ae Lee2, il Han Song1
1Departments of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea
2Departments of Pathology, Dankook University College of Medicine, Cheonan, Korea
Correspondence:  il Han Song,
Email: ihsong21@dankook.ac.kr
Copyright ©2016 by The Korean Liver Cancer Association
Sarcomatoid carcinoma arising from intrahepatic cholangiocyte, an extremely rare primary liver cancer, has highly invasive and metastatic potential. The pathogenesis of this tumor is unclear, although histogenetic mechanisms, such as transdifferentiation/dedifferentiation (epithelialmesenchymal transition or metaplastic transformation), biphasic differentiation (combination and collision), and redifferentiation, might be suggested to explain the simultaneous coexistence of carcinoma and sarcoma components in the same tumor. Immunohistochemical staining might be necessary to differentiate whether sarcomatous component is originated from hepatocyte or cholangiocyte. We report a case of sarcomatoid intrahepatic cholangiocarcinoma in a 58 year-old man presenting as an incidentally detected liver mass on regular health examination, which was diagnosed by an application of immunohistochemical methods after surgical resection, with a review of the literature based on 9 cases reported in Korea.
Key Words: Sarcomatoid carcinoma; Cholangiocarcinoma; Liver neoplasm
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