| Sarcomatoid Intrahepatic Cholangiocarcinoma: A Rare Case of Primary Liver Cancer |
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Doo Hyuck Lee1, Kyu Hyung Han1, Sun Young Ahn1, Sang Sun Kim1, Hyun Sung Shin1, Ki Bae Bang1, Jun Ho Choi1, Suk Bae Kim1, Won Ae Lee2, il Han Song1 |
1Departments of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea
2Departments of Pathology, Dankook University College of Medicine, Cheonan, Korea |
Correspondence:
il Han Song,
Email: ihsong21@dankook.ac.kr
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| Abstract |
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Sarcomatoid carcinoma arising from intrahepatic cholangiocyte, an extremely rare primary liver
cancer, has highly invasive and metastatic potential. The pathogenesis of this tumor is unclear,
although histogenetic mechanisms, such as transdifferentiation/dedifferentiation (epithelialmesenchymal
transition or metaplastic transformation), biphasic differentiation (combination
and collision), and redifferentiation, might be suggested to explain the simultaneous coexistence
of carcinoma and sarcoma components in the same tumor. Immunohistochemical
staining might be necessary to differentiate whether sarcomatous component is originated from
hepatocyte or cholangiocyte. We report a case of sarcomatoid intrahepatic cholangiocarcinoma
in a 58 year-old man presenting as an incidentally detected liver mass on regular health
examination, which was diagnosed by an application of immunohistochemical methods
after surgical resection, with a review of the literature based on 9 cases reported in Korea. |
| Key Words:
Sarcomatoid carcinoma; Cholangiocarcinoma; Liver neoplasm |
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