A Case of Advanced Hepatocellular Carcinoma with Portal Vein Tumor Invasion that Showed Favorable Prognosis after Combined External Radiation Therapy and Sorafenib Therapy

Paik, Namyoung; Sinn, Dong Hyun; Park, Hee Chul; Jeong, Woo Kyung; Kim, Min Sun; Kim, Ji Hye; Yang, Bumhee

doi:2016.16.2.134

J Liver Cancer > Volume 16(2); 2016 > Article

Case Report

Journal of Liver Cancer 2016;16(2):134-138.
DOI: https://doi.org/10.17998/jlc.16.2.134 Published online September 30, 2016.

A Case of Advanced Hepatocellular Carcinoma with Portal Vein Tumor Invasion that Showed Favorable Prognosis after Combined External Radiation Therapy and Sorafenib Therapy

Namyoung Paik¹, Dong Hyun Sinn¹, Hee Chul Park², Woo Kyung Jeong³, Min Sun Kim¹, Ji Hye Kim¹, Bumhee Yang¹

¹Departments of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine,Seoul, Korea
²Departments of Radio-oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine,Seoul, Korea
³Departments of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine,Seoul, Korea

Correspondence: Dong Hyun Sinn,
Email: dh.sinn@samsung.com

Abstract

A prognosis of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is dismal that the median survival is 2 to 4 months without treatment. Sorafenib, the standard regimen of advanced HCC, can prolong median survival only 1.5 months. A 50-year-old man with a history of chronic hepatitis B was diagnosed advanced HCC with PVTT. By a multidisciplinary medical team approach, the combination of 3-demensional conformal radiation therapy with sequential sorafenib was challenged. 4 months after initiation of treatment, he achieved partial response as modified response evaluation criteria in solid tumors criteria. Sorafenib was continued so far, and stable disease has been maintained up to now, without significant adverse effect.

Key Words: Hepatocellular carcinoma; Sorafenib; Radiation therapy

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