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J Liver Cancer > Volume 15(1); 2015 > Article
Journal of Liver Cancer 2015;15(1):30-35.
DOI: https://doi.org/10.17998/jlc.15.1.30    Published online March 31, 2015.
Loss of Liver Fatty Acid Binding Protein Expression in Hepatocellular Carcinomas is Associated with a Decreased Recurrence-Free Survival
Haeryoung Kim1, Hyejung Lee1, Young Nyun Park2
1Department of Pathology,Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam
2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
Correspondence:  Young Nyun Park,
Email: young0608@yuhs.ac
Abstract
Background/Aims
Loss of liver fatty acid binding protein (LFABP) expression by immunohistochemistry is a useful marker for the identification of hepatocyte nuclear factor 1α (HNF1α)- inactivated hepatocellular adenomas; however, the expression status of LFABP in hepatocellular carcinomas (HCCs) is still unclear. We aimed to investigate the expression status of LFABP in HCCs and examine the clinicopathological characteristics of LFABP-negative HCCs.
Methods
Immunohistochemical stains LFABP, K19 (mouse monoclonal, Dako, Glostrup, Denmark) and EpCAM (mouse monoclonal, Calbiochem, Darmstadt, Germany) were performed on tissue microarray sections from 188 surgically resected HCCs, and the association between LFABP expression status and the clinicopathological features, survival and “stemness”-related marker expression status were analyzed.
Results
Loss of LFABP expression was noted in 30 (16%) out of 188 HCCs. LFABP-negative HCCs were associated with a decreased recurrence-free survival (LFABP-negative: 17.0 ± 4.84 months [95% confidence interval [CI]: 7.5–26.5 months] versus LFABP-positive: 51.0 ± 8.7 months [95% CI: 34.0–68.0 months]; P=0.004). HCCs with LFABP expression loss were more frequently larger and showed more frequent vascular invasion, although not statistically significant; and an inverse correlation was seen between LFABP expression and K19 expression status (P=0.001).
Conclusions
Loss of LFABP expression is seen in HCCs, and is associated with a decreased recurrence-free survival.
Key Words: Hepatocellular carcinoma; Liver fatty-acid binding protein; Immunohistochemistry; Prognosis
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