Transarterial Chemoembolization versus Radiofrequency Ablation for Small Hepatocellular Carcinomas with Discrepant Features on Computed Tomography and Magnetic Resonance Imaging

Cho, Young Youn; Kwon, Jung Hee; Lee, Jeong-Hoon; Lee, Jeong Min; Lee, Jae Young; Kim, Hyo-Choel; Chung, Jin Wook; Choi, Won-mook; Cho, Eun Ju; Kim, Yoon Jun; Yoon, Jung-Hwan; Kim, Chung Yong; Lee, Hyo-Suk

doi:2015.15.1.19

J Liver Cancer > Volume 15(1); 2015 > Article

Original Article

Journal of Liver Cancer 2015;15(1):19-29.
DOI: https://doi.org/10.17998/jlc.15.1.19 Published online March 31, 2015.

Transarterial Chemoembolization versus Radiofrequency Ablation for Small Hepatocellular Carcinomas with Discrepant Features on Computed Tomography and Magnetic Resonance Imaging

Young Youn Cho¹, Jung Hee Kwon¹, Jeong-Hoon Lee¹, Jeong Min Lee², Jae Young Lee², Hyo-Choel Kim², Jin Wook Chung², Won-mook Choi¹, Eun Ju Cho¹, Yoon Jun Kim¹, Jung-Hwan Yoon¹, Chung Yong Kim¹, Hyo-Suk Lee¹

¹Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine, Seoul, Korea
²Department of Radiology,Seoul National University College of Medicine, Seoul, Korea

Correspondence: Jeong-Hoon Lee,
Email: pindra@empal.com

Abstract

Background/Aims
This study compared the outcomes of patients with small hepatocellular carcinomas (HCCs) who were treated using transarterial chemoembolization (TACE) or radiofrequency ablation (RFA).
Methods
This was a post-hoc analysis of a prospective study that evaluated the diagnostic efficacy of magnetic resonance imaging (MRI) and computed tomography (CT). We analyzed 41 small hepatic nodules in 32 patients that showed typical radiologic hallmarks on both CT and gadoxate-enhanced MRI (typical nodules) and 25 small hepatic nodules from 22 patients that showed atypical radiologic hallmarks on CT and typical radiologic hallmarks on MRI (discrepant nodules).
Results
There were no significant differences in the baseline characteristics of the patients with typical and discrepant nodules. Complete response rates 1 month after TACE or RFA were 75.0% (18/24) and 94.1% (16/17; P=0.20), respectively, for the patients with typical nodules and 58.8% (10/17) and 100% (8/8; P=0.05), respectively, for the patients with discrepant nodules. Treatment failure rates after TACE or RFA were 33.3% (8/24) and 5.8% (1/17; P=0.15), respectively, for the patients with typical nodules and 47.0% (8/17) and 0.0% (0/8; P=0.02), respectively, for the patients with discrepant nodules. Among patients achieving complete response, there were no significant differences in the risk of marginal recurrence.
Conclusions
RFA provided higher complete response rates and significantly lower treatment failure rates than TACE for patients with discrepant nodules of HCC. Therefore, a treatment modality such as RFA may be preferable for small HCCs which show discrepancy on two imaging modalities.

Key Words: Hepatocellular carcinoma; Multidetector computed tomography; Magnetic resonance imaging

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