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J Liver Cancer > Volume 14(2); 2014 > Article
Journal of the Korean Liver Cancer Study 2014;14(2):127-130.
DOI: https://doi.org/10.17998/jlc.14.2.127    Published online September 30, 2014.
A Case of Positive Tumor Marker Response after Intra-arterial Deferoxamine Infusion Therapy in a Hepatocellular Carcinoma Patient with Decompensated Liver Function
Hyun Ju Kim1, Wonseok Kang1, Mi Na Kim1,2, Beom Kyung Kim1,2,3, Seung Up Kim1,2,3, Do Young Kim1,2,3, Sang Hoon Ahn1,2,3, Kwang-Hyub Han1,2,3
1Department of Internal Medicine, Yonsei University College of Medicine
2Institute of Gastroenterology, Yonsei University College of Medicine
3Liver Cirrhosis Clinical Research Center, Yonsei University College of Medicine
Correspondence:  Kwang-Hyub Han,
Email: gihankhys@yuhs.ac.kr
Copyright ©2014 by The Korean Liver Cancer Association
Abstract
Treatment of hepatocellular carcinoma is often very challenging when the underlying liver function is decompensated. Recent experimental and clinical studies showed that some chelating agents, including deferoxamine, display anti-proliferative actions against tumor cells, thereby exhibiting anti-cancer effect in certain cancers, including hepatocellular carcinoma. Based on previous studies, we herein offer our experience of positive tumor marker response after intra-arterial deferoxamine infusion in a patient presenting with advanced hepatocellular carcinoma with decompensated hepatic function. Validation of the efficacy of intra-arterial deferoxamine therapy in the setting of advanced hepatocellular carcinoma with underlying decompensated hepatic function is warranted. (J Liver Cancer 2014;14:127-130)
Key Words: Hepatocellular carcinoma; Decompensated liver cirrhosis; Deferoxamine
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