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J Liver Cancer > Volume 13(1); 2013 > Article
Journal of the Korean Liver Cancer Study Group 2013;13(1):57-61.
DOI: https://doi.org/10.17998/jlc.13.1.57    Published online February 28, 2013.
A Case of Huge Hepatocellular Carcinoma with Complete Remission of Intrahepatic Tumor and Adrenal Gland Metastasis Treated with Combination Therapy of Transarterial Chemoembolization and Radiation Therapy and Sorafenib
Sang Youn Hwang1, Seon-Mi Lee1, Jung Woo Im1, Joon Suk Kim1, Sang Bu Ahn2, Eun Kyeong Ji2, Chul Won Choi3, Gwang-Mo Yang3
1Department of Internal Medicine and Gastrointestinal Cancer Center, Dongnam Institute of Radiation & Medical Sciences, Busan, Korea
2Departement of Radiology, Dongnam Institute of Radiation & Medical Sciences, Busan, Korea
3Department of Radiation Oncology, Dongnam Institute of Radiation & Medical Sciences, Busan, Korea
Correspondence:  Sang Youn Hwang,
Email: mongmani@daum.net
Abstract
Extrahepatic metastasis (EHM) associated with hepatocellular carcinoma (HCC) has been increasing due to prolonged survival with recent advances in therapeutic approaches including locoregional therapy such as transarterial chemoemoblization (TACE), radiofrequency ablation and radiation therapy (RT). Though many guidelines recommended systemic therapy such as sorafenib in this situation, some clinicians or centers still select locoregional therapy because the survival improvement of 2 or 3 months by sorafenib is far from optimal. Moreover, some studies showed that complete and partial response of intrahepatic tumors can result in significant improvement of patient survival even in situation of EHM. Based on above suggestions, we herein offer our experience of a patient with complete remission of intrahepatic tumor and adrenal gland metastasis treated with combination therapy of TACE and RT and sorafenib. Further study, maybe regarding a combination of locoregional and systemic therapy (so called multidisciplinary approach), is necessary on how to manage HCC patients with EHM.
Key Words: Hepatocellular carcinoma; Extrahepatic metastasis; Trasnarterial chemoembolization; Radiation therapy
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