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Journal of the Korean Liver Cancer Study Group 2012;12(1):62-66.
Published online February 28, 2012.
A Case of Liver Transplantation after Combination of Sorafenib and Hepatic Arterial Infusion Chemotherapy in the Advanced Hepatocellular Carcinoma Patient with Portal Vein Thrombosis
Do Seon Song1, Myeong Jun Song1, Si Hyun Bae1, Jong Young Choi1, Seung Kew Yoon1, Ho Jong Chun2, Dong Goo Kim3
1Departments of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
2Departments of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Korea
3Departments of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea
Correspondence:  Myeong Jun Song,
Email: mjsong95@gmail.com
Abstract
Hepatocellular carcinoma (HCC) is the third most common malignancy in Korea where chronic hepatitis B virus is prevalent. More than 60-70% of HCC cases are diagnosed at an advanced stage that are not eligible for curative therapy such as surgical resection, liver transplantation, radiofrequency ablation, and percutaneous ethanol injection. According to Barcellona Clinic Liver Cancer (BCLC) staging and treatment, standard treatment of advanced HCC is sorafenib. And there are some reports that hepatic arterial infusion chemotherapy (HAIC) could be a beneficial therapeutic option for patients with advanced HCC. We report a case of advanced HCC with portal vein thrombosis that received liver transplantation after combination treatment of HAIC and sorafenib.
Key Words: Hepatocellular carcinoma; Sorafenib; Hepatic arterial infusion chemotherapy
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