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HOME > J Liver Cancer > Volume 11(2); 2011 > Article
Review Article The Role of TIS21/BTG2/PC3 during Hepatocarcinogenesis
Tae Jun Park
Journal of Liver Cancer 2011;11(2):130-135
Published online: September 30, 2011
Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea
Corresponding author:  Tae Jun Park,
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A functional and biochemical features of TIS21(/BTG2/PC3) was explored in hepatocarcinogenesis. Growth of hepatocellular carcinoma (HCC), developed by a single injection of diethylnitrosamine (DEN) was significantly higher in the TIS21 knockout mice at 9 months. Expression of BTG2/TIS21 was significantly lower in both human and mouse hepatocellular carcinoma than in the surrounding normal tissues. Over-expression of TIS21 inhibited cell proliferation and tumorigenic potential of Huh7 hepatoma cells. At the molecular mechanistic level, TIS21 inhibited FoxM1 phosphorylation, by reducing cyclin B1-cdk1 activity. Furthermore, TIS21 inhibited FoxM1 transcriptional activity. In conclusion, TIS21 negatively regulated hepatocarcinogenesis in part by disruption of the FoxM1-cyclin B1 regulatory loop, thereby inhibiting proliferation of transformed cells developed in mouse and human livers.

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