Recent progress in imaging techniques has permitted the diagnosis of hepatocelluar carcinoma (HCC) at an early stage. However, portal vein invasion is still found in 12.5~39.7%. HCC with tumor thrombosis of the portal vein has a poor prognosis. Previous studies showed that the median survival time of patients with HCC with involving portal vein was 2.7~4 months if effective treatment was not administered. Thus, for such HCC with portal vain invasion, an effective therapy that will maintain quality of life is required. We report a case of HCC with portal vein tumor thrombus treated by intra-arterial chemotherapy.