J Liver Cancer Search


Journal of the Korean Liver Cancer Study 2009;9(1):1-6.
Published online June 30, 2009.
Prediction of Tumor Biology in Hepatocellular Carcinoma
Won Kim
Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea
Correspondence:  Won Kim,
Email: wonshiri@yahoo.com
Copyright ©2009 by The Korean Liver Cancer Association
Hepatocellular carcinoma (HCC) surveillance programs have led to an increase in the adoption of radical therapies. Nevertheless, HCCs often present at an advanced stage and the prognosis remains dismal even after resection due to the high rate of recurrence. The study of tumor biology is important to predict clinical outcome enabling more appropriate therapeutic decisions for HCC patients. Understanding molecular mechanisms of hepatocarcinogenesis may also lead to effective strategies in chemoprevention. However, current staging systems based on clinicopathologic factors are limited in prognostic prediction. Recently, there has been great interest in the study of gene expression profile in relation to prognosis of HCC. Global gene expression profiling may be the most appropriate technology to unravel the pathogenesis of HCC and explore its heterogeneous origin. The elucidation of tumor biology of HCC is of paramount clinical importance in the new era of molecular target therapy.
Key Words: Hepatocarcinogenesis; Tumor biology; Molecular; Gene expression

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