Hepatocellular carcinoma (HCC) is an aggressive tumor that frequently occurs in the setting of chronic liver disease and cirrhosis. It is typically diagnosed late in the course of chronic liver disease, with the median survival following diagnosis of approximately 6 to 20 months. Although the mainstay of therapy is surgical resection, several other treatment modalities may also have a role. The patient’s hepatic reserve often dictates therapeutic options. Treatment options are divided into surgical therapies (i.e., resection, cryoablation, and orthotopic liver transplantation), and nonsurgical therapies (i.e., percutaneous ethanol injection, radiofrequency ablation, transarterial chemoembolization, systemic chemotherapy, or radiotherapy). Here we report a case of successfully treated HCC with combined therapy of surgical and nonsurgical modalities.