Obstructive jaundice is a rare initial symptom of hepatocellular carcinoma (HCC) patients. We herein report a patient with extrahepatic bile duct HCC mimicking common bile duct (CBD) cancer. A 55-year-old woman with no risk factors developed jaundice of the obstructive type. On dynamic computed tomography, a low attenuated mass located in the lumen of CBD with the invasion of right posterior hepatic parenchyma was identified. After percutaneous transhepatic biliary drainage, we performed hepatectomy. Pathologic examination of the lesion confirmed the diagnosis of hepatocellular carcinoma with biliary cell differentiation extended in the CBD.