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Journal of the Korean Liver Cancer Study Group 2007;7(1):55-58.
Published online June 30, 2007.
A Case of Combined Hepatocellular-Cholangiocarcinoma Mimicking Focal Nodular Hyperplasia
Dong Hyun Shin1, Kwang Cheol Koh1, Geum Youn Gwak1, Dong Il Choi2, Cheol Keun Park3, Moon Seok Choi1, Joon Hyoek Lee1, Seung Woon Paik1, Byung Chul Yoo1
1Departments of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
2Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
3Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Correspondence:  Kwang Cheol Koh,
Email: kc.koh@samsung.com
Abstract
Combined hepatocellular and cholangiocarcinoma (cHCC-CC) is an uncommon form of primary liver cancer having features of both hepatocellular and billiary epithelial differentiation. We report a case of cHCC-CC in a patient who was serologically positive for hepatitis B virus. A 39-year-old male was diagnosed by ultrasonography with an asymptomatic tumor in the left lobe of the liver. Based on radiologic and serologic findings of elevated serum alpha-fetoprotein level, a preoperative diagnosis of hepatocellular carcinoma was made, but differential diagnosis included focal nodular hyperplasia, because tumor was enhanced in delayed phase in Godolinium MRI scan. A final diagnosis of cHCC-CC was made after operation.
Key Words: Combined hepatocellular and cholangiocarcinoma; Focal nodular hyperplasia
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