A Case of Combined Hepatocellular-Cholangiocarcinoma Mimicking Focal Nodular Hyperplasia

Shin, Dong Hyun; Koh, Kwang Cheol; Gwak, Geum Youn; Choi, Dong Il; Park, Cheol Keun; Choi, Moon Seok; Lee, Joon Hyoek; Paik, Seung Woon; Yoo, Byung Chul

Case Report

Journal of the Korean Liver Cancer Study Group 2007;7(1):55-58.
Published online June 30, 2007.

A Case of Combined Hepatocellular-Cholangiocarcinoma Mimicking Focal Nodular Hyperplasia

Dong Hyun Shin¹, Kwang Cheol Koh¹, Geum Youn Gwak¹, Dong Il Choi², Cheol Keun Park³, Moon Seok Choi¹, Joon Hyoek Lee¹, Seung Woon Paik¹, Byung Chul Yoo¹

¹Departments of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
²Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
³Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Correspondence: Kwang Cheol Koh,
Email: kc.koh@samsung.com

Abstract

Combined hepatocellular and cholangiocarcinoma (cHCC-CC) is an uncommon form of primary liver cancer having features of both hepatocellular and billiary epithelial differentiation. We report a case of cHCC-CC in a patient who was serologically positive for hepatitis B virus. A 39-year-old male was diagnosed by ultrasonography with an asymptomatic tumor in the left lobe of the liver. Based on radiologic and serologic findings of elevated serum alpha-fetoprotein level, a preoperative diagnosis of hepatocellular carcinoma was made, but differential diagnosis included focal nodular hyperplasia, because tumor was enhanced in delayed phase in Godolinium MRI scan. A final diagnosis of cHCC-CC was made after operation.

Key Words: Combined hepatocellular and cholangiocarcinoma; Focal nodular hyperplasia

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