A Case of Combined Hepatocellular-Cholangiocarcinoma Mimicking Focal Nodular Hyperplasia |
Dong Hyun Shin1, Kwang Cheol Koh1, Geum Youn Gwak1, Dong Il Choi2, Cheol Keun Park3, Moon Seok Choi1, Joon Hyoek Lee1, Seung Woon Paik1, Byung Chul Yoo1 |
1Departments of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 3Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea |
Correspondence:
Kwang Cheol Koh, Email: kc.koh@samsung.com |
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Abstract |
Combined hepatocellular and cholangiocarcinoma (cHCC-CC) is an uncommon form of primary liver cancer
having features of both hepatocellular and billiary epithelial differentiation. We report a case of cHCC-CC in a
patient who was serologically positive for hepatitis B virus. A 39-year-old male was diagnosed by
ultrasonography with an asymptomatic tumor in the left lobe of the liver. Based on radiologic and serologic
findings of elevated serum alpha-fetoprotein level, a preoperative diagnosis of hepatocellular carcinoma was made,
but differential diagnosis included focal nodular hyperplasia, because tumor was enhanced in delayed phase in
Godolinium MRI scan. A final diagnosis of cHCC-CC was made after operation. |
Key Words:
Combined hepatocellular and cholangiocarcinoma; Focal nodular hyperplasia |
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