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THE KOREAN LIVER CANCER ASSOCIATION
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- Case Report A Case of Complete Regression of Hepatocellular Carcinoma during COX-2 Inhibitor Administration
- Hae Jung Song1, Yun Soo Kim1, Chang Hee Han1, Jae Young Jang1, Jung Hoon Kim2, Young Koog Cheon1, Young Seok Kim1, Jong Ho Moon1, Young Deok Cho1, Chan Sup Shim1, Boo Sung Kim1
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Journal of Liver Cancer 2006;6(1):65-69
DOI: https://doi.org/
Published online: June 30, 2006
1Institute for Digestive Research, Departments of Internal Medicine, Soon Chun Hyang University College of Medicine, Seoul, Korea
2Departments of Radiology, Soon Chun Hyang University College of Medicine, Seoul, Korea
2Departments of Radiology, Soon Chun Hyang University College of Medicine, Seoul, Korea
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Corresponding author:
Chan Sup Shim,
Email: schidr@hosp.sch.ac.kr
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Abstract
Overexpression of cyclooxygenase-2 (COX-2) has been associated with hepatocarcinogenesis. Inhibitors of COX-2 have proapoptotic and antiproliferative effects on malignant tumors and inhibit their invasion to surrounding tissues. We report a case of complete regression of advanced HCC during COX-2 inhibitor administration. An eighty-year-old female was diagnosed as advanced hepatocellular carcinoma (HCC) which was associated with HCV infection. She received COX-2 inhibitor for 3 months due to degenerative arthritis of both knees. Tumor enhancement on arterial phase was completely disappeared without specific treatment for the HCC, and the size of mass markedly decreased on follow-up CT scan.
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