Prognosis of advanced hepatocellular carcinoma (HCC) treated by conventional therapies has been considered to be poor. Hepatic arterial infusion therapy (HAIT) has been tried for advanced hepatocellular carcinoma with portal vein tumor thrombosis or ineffective response to other treatment. We report two cases of advanced HCC showing good respense to transarterial chemoembolization and CT guided percutaneous ethanol injection therapy.