The use of transarterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma (HCC) has become increasingly popular in the last 20 years. By TACE overall survival might be prolonged in patients with moderately advanced HCC, and some surgically untreatable tumors have been rendered resectable subsequently and some patients achieved cures. However, it would be recommended to proceed with liver resection when we were unable to ascertain clinically the complete success of post-TACE tumor destruction, even when the size of the huge tumor was reduced obviously and the alpha-fetoprotein returned to normal after TACE treatments. Sequential surgical resection has been advocated for a curative outcome even after effective TACE treatments. We report a case of successful hepatic resection with right hepatic vein and its adjacent IVC after TACE and perfusion chemotherapy for huge HCC with tumor thrombus extending into IVC.