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Journal of the Korean Liver Cancer Study 2006;6(1):7-11.
Published online June 30, 2006.
Efficacy of Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma
Sihyun Bae
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
Correspondence:  Sihyun Bae,
Email: baesh@catholic.ac.kr
Copyright ©2006 by The Korean Liver Cancer Association
Hepatocellular carcinoma (HCC) ranks as the 3rd most common cancer in Korea. At the time of presentation with HCC, many patients have poor hepatic reserve function and advanced HCC with portal vein thrombosis (PVT) that precludes effective therapy. Surgical resection is the 1st choice treatment but, it is not a suitable option for patients with advanced disease. Other treatment modalities, which have been used for unresectable HCC with PVT, include systemic chemotherapy, hepatic arterial chemotherapy, tumor embolization, radiation therapy, and a combination of the above. Because of the fatal toxicities often encountered with TACE in advanced HCC patients with PVT, hepatic arterial infusion chemotherapy is an alternative modality. This method enable repeated chemotherapy infusions into the HCC lesions, and allows generating high antitumor effect and low adverse effects such as hepatic artery occlusion or stenosis. In this review, the principles and efficacy of hepatic arterial infusion chemotherapy for treatment of advanced HCC are reviewed. In the future, we need large scaled prospective randomized trials to determine the definite role of this hepatic arterial infusion chemotherapy.
Key Words: Hepatocellular carcinoma; Transcatheter artrerial chemoembolization; Transcatheter artrerial chemoembolization


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