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THE KOREAN LIVER CANCER ASSOCIATION
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Case Report
- Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma
- Allison Kaye L. Pagarigan, Paulo Giovanni L. Mendoza
- J Liver Cancer. 2023;23(1):219-224. Published online March 13, 2023
- DOI: https://doi.org/10.17998/jlc.2023.02.24
- 1,782 Views
- 67 Downloads
- 3 Citations
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Abstract
PDF - Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatric cases reported in literature. Recounted is a case of a 49-year-old female who presented with acute right upper quadrant abdominal pain, elevated serum alpha fetoprotein and a large liver mass on imaging. Hepatectomy was performed under clinical suspicion of hepatocellular carcinoma. Immunomorphologic characteristics of the tumor proved consistent with hepatoblastoma of mixed epithelial and mesenchymal type. Hepatocellular carcinoma remains to be the primary differential diagnosis for adult hepatoblastoma, however, distinguishing between these two neoplasms requires close histomorphologic assessment and immunohistochemical profiling as clinical, radiologic and gross pathologic findings typically overlap. Making this distinction is highly crucial in the timely initiation of surgical and chemotherapeutic interventions for this inherently aggressive and rapidly fatal disease.
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Citations
Citations to this article as recorded by
- Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care Center
Divya Achutha Ail, Malini Eapen, Pavithran Keechilat, Sudheendran Surendran, Naveen Viswanath
Indian Journal of Medical and Paediatric Oncology.2025;[Epub] CrossRef - Blastomas of the digestive system in adults: A review
Yu Liu, Tony El Jabbour, Jonathan Somma, Yukihiro Nakanishi, Saverio Ligato, Hwajeong Lee, Zhi-Yan Fu
World Journal of Gastrointestinal Surgery.2024; 16(4): 1030. CrossRef - Adult Hepatoblastoma and Concomitant Hepatitis B Infection
Alejandro Nieto Dominguez, Sarah Elizabeth Eichinger, Elza Matrova, Anas Almoghrabi
ACG Case Reports Journal.2024; 11(9): e01491. CrossRef
- Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care Center
Review Article
- Recent updates on the classification of hepatoblastoma according to the International Pediatric Liver Tumors Consensus
- Se Un Jeong, Hyo Jeong Kang
- J Liver Cancer. 2022;22(1):23-29. Published online March 17, 2022
- DOI: https://doi.org/10.17998/jlc.2022.02.24
- 9,587 Views
- 675 Downloads
- 6 Citations
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Abstract
PDF
- Hepatoblastoma is the most common pediatric liver malignancy and usually occurs within the first 3 years of life. In recent years, the overall incidence of hepatoblastoma has exhibited the greatest increase among all pediatric malignancies worldwide. The diagnosis of hepatoblastoma may be challenging due to the lack of a current consensus classification system. The International Pediatric Liver Tumors Consensus introduced guidelines and a consensus classification for the diagnosis of hepatoblastoma as either epithelial or mixed epithelial and mesenchymal and in the updated 5th edition of the World Health Organization Classification of Digestive System Tumors.
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Citations
Citations to this article as recorded by- Tumor‐associated macrophages: The key player in hepatoblastoma microenvironment and the promising therapeutic target
Ahmad Adawy, Yoshihiro Komohara, Taizo Hibi
Microbiology and Immunology.2024; 68(8): 249. CrossRef - Hepatoblastoma: A Case Report
Abel Ning Caballero, Kandecy Archer-Austin
Asploro Journal of Biomedical and Clinical Case Reports.2024; 7(3): 226. CrossRef - Adult Hepatoblastoma and Concomitant Hepatitis B Infection
Alejandro Nieto Dominguez, Sarah Elizabeth Eichinger, Elza Matrova, Anas Almoghrabi
ACG Case Reports Journal.2024; 11(9): e01491. CrossRef - Metabolic and Epigenetic Mechanisms in Hepatoblastoma: Insights into Tumor Biology and Therapeutic Targets
Yuanji Fu, Raquel Francés, Claudia Monge, Christophe Desterke, Agnès Marchio, Pascal Pineau, Yunhua Chang-Marchand, Jorge Mata-Garrido
Genes.2024; 15(11): 1358. CrossRef - Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma
Allison Kaye L. Pagarigan, Paulo Giovanni L. Mendoza
Journal of Liver Cancer.2023; 23(1): 219. CrossRef - Advances in Histological and Molecular Classification of Hepatocellular Carcinoma
Joon Hyuk Choi, Swan N. Thung
Biomedicines.2023; 11(9): 2582. CrossRef
- Tumor‐associated macrophages: The key player in hepatoblastoma microenvironment and the promising therapeutic target
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