Journal of Liver Cancer

Case Report

Thrombotic Occlusion of Right Femoral Artery Developed during Intra-Arterial Chemotherapy Through Chemoport: Jae Pil Han, Young Seok Kim, Sae Hwan Lee, Soung Won Jeong, Sang Gyune Kim, Jae Young Jang, Hong Soo Kim, Jae Myeong Lee, Boo Sung Kim; Journal of the Korean Liver Cancer Study Group. 2011;11(2):199-202. Published online September 30, 2011

Abstract PDF: Although chemotherapy may not play a central role in the treatment of hepatocellular carcinoma (HCC), it must be one of the important possibilities of multimodal treatment for advanced HCC. Intra-arterial (IA) chemotherapy which can deliver high concentration of drug to the tumor has been widely used in unresectable or intractable HCC. It seems to reduce the incidence of systemic side effects and improve drug efficacy. For this therapy, catheter implantation is required to infuse anti-tumor drug. Here, we report a case of patient with complication developed during IA chemotherapy for advanced HCC with portal vein thrombosis.

Review Article

Hepatocellular Carcinoma Invading Bile Duct: Geum Youn Gwak; Journal of the Korean Liver Cancer Study Group. 2008;8(1):1-7. Published online June 30, 2008

Abstract PDF: Although invasion of portal veins and hepatic veins is common in hepatocellular carcinoma (HCC), macroscopic bile duct invasion is rare. Bile duct thrombi have been identified in 0.5% to 9% of HCC patients. In general, these patients have a worse clinical course and shorter survival than patients without bile duct thrombi, probably attributable to the low resectability rate secondary to poor functional reserve caused by obstructive jaundice and cholangitis, and combined major vascular invasion. However, a few data demonstrated that an aggressive operative approach after appropriate preoperative management offered a better chance of long-term survival in some patients with HCC with bile duct thrombi. Herein, we describe some cases of HCC with bile duct thrombi and summarize clinical features and treatment outcomes on the basis of the literatures published to date.

Case Reports

A Case of Hepatocellular Carcinoma With Bile Duct Thrombi Presenting Obstructive Jaundice: Su Rin Shin, Geum-Youn Gwak, Cheol Keun Park, Won Jae Lee, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Won Paik, Byung Chul Yoo; Journal of the Korean Liver Cancer Study Group. 2008;8(1):47-50. Published online June 30, 2008

Abstract PDF: Although invasion into blood vessels, particularly the portal vein, is a common feature of hepatocellular carcinoma (HCC), intrabile duct invasion has been considered rare. HCC with bile duct thrombi is occasionally misdiagnosed as biliary carcinoma or stone, and tends to have a worse clinical course than HCC without bile duct thrombi, probably attributable to the low resectability rate secondary to poor functional reserve caused by obstructive jaundice, and combined major vascular invasion. However, a few data demonstrated that obstructive jaundice aroused an early detection of HCC, leading to a better survival. Herein, we describe a case of HCC with bile duct thrombi, which was diagnosed at an early stage with obstructive jaundice and had a favorable course after surgical resection.

Effect of combination therapy with TACE and 3D-CRT for two patients with PVT and/or IVC tumor thrombus: Hyun Deok Shin, Young-Suk Lim, Soon Joo Kim, Sang Hyun Park, Gang Mo Kim, Han Chu Lee, Young Hwa Jung, Young Sang Lee, Dong Jin Suh; Journal of the Korean Liver Cancer Study Group. 2007;7(1):87-93. Published online June 30, 2007

Abstract PDF: Advanced hepatocellular carcinoma has a poor prognosis, especially in the cases with portal vein or IVC tumor thrombi. In such cases, surgical resection could not be a curative treatment option and transcatheter arterial chemoembolization (TACE) alone is usually ineffective. Recently, three-dimensional conformal radiation therapy (3D-CRT) has been developed to better conform the radiation dose to the tumor volume in order to reach the goal of eradicating local disease without injuring normal tissue. Combination therapy with TACE and 3D-CRT could be considered as a treatment option for advanced HCC with PV or IVC tumor thrombi. We report here two cases with advanced HCC showing response to combination therapy with repeated TACE and 3D-CRT.

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