Journal of Liver Cancer

2 "Response assessment"

Filter

Article category

Publication year

Review Articles

Response Evaluation Assessment in HCC: Modified RECIST: So Yeon Kim; Journal of the Korean Liver Cancer Study Group. 2011;11(2):111-115. Published online September 30, 2011

Abstract PDF: The accurate evaluation of response to treatment is a key aspect in cancer therapy, because an objective response may become a surrogate marker of improver survival. For cytotoxic drugs, tumor response evaluation according to the World Health Organization (WHO) criteria or the Response Evaluation Criteria in Solid Tumors (RECIST) guideline offers simple approaches based on the size of the lesions. However, considering the nature of locoregional therapy or new cytostatic agent for hepatocellular carcinoma (HCC), which do not decrease the size of the tumor but induce tumor necrosis, original WHO or RECIST criteria will not reflect clinical benefit exactly. Recently, modified RECIST assessment is proposed by AASLD-JNCI guidelines. Given that complete necrosis was well correlated with better survival, modified RECIST criteria consider changes in tumor viability, which can be measured as the area of arterial enhancement, with maintaining overall response assessment similar to RECIST. The proposed modified RECIST assessment is expected to provide a reliable method for assessing tumor response in HCC clinical trials.

Radiological Evaluation of Treatment Response of Hepatocellular Carcinoma: Yong Moon Shin; Journal of the Korean Liver Cancer Study Group. 2011;11(1):12-17. Published online February 28, 2011

Abstract PDF: For hepatocelluar carcinoma(HCC), there are several treatment options such as transcatheter arterial chemoembolization (TACE), radiofrequency ablation (RFA), and radiation therapy. It is essential to be familiar with the radiologic findings to know whether the residual or recurrent tumor exist after treatment. But, radiological image findings show complex responses according to the initial tumor morphology and treatment methods. One purpose of this article is to discuss the guidelines to evaluate the tumor response of HCC after treatment. And the other purpose is to evaluate the imaging features of HCC after various treatment
methods
and to reveal the limitations of each imaging technique in evaluating the therapeutic effect on HCC.

Search