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Review Article
- Current perspectives on radiotherapy in hepatocellular carcinoma management: a comprehensive review
- Dowook Kim, Jun-Sang Kim
- J Liver Cancer. 2024;24(1):33-46. Published online March 25, 2024
- DOI: https://doi.org/10.17998/jlc.2024.02.26
- 13,025 Views
- 484 Downloads
- 6 Citations
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Abstract
PDF - This review examines the transformative role of external beam radiotherapy (EBRT) in managing hepatocellular carcinoma (HCC), spotlighting the progression from traditional EBRT techniques to advanced modalities like intensity-modulated radiotherapy (RT), stereotactic body RT (SBRT), and innovative particle therapy, including proton beam therapy and carbon ion RT. These advancements have significantly improved the precision and efficacy of RT, marking a paradigm shift in the multimodal management of HCC, particularly in addressing complex cases and enhancing local tumor control. The review underscores the synergistic potential of integrating RT with other treatments like transarterial chemoembolization, systemic therapies such as sorafenib, and emerging immunotherapies, illustrating enhanced survival and disease control outcomes. The efficacy of RT is addressed for challenging conditions, including advanced HCC with macrovascular invasion, and RT modalities, like SBRT, are compared against traditional treatments like radiofrequency ablation for early-stage HCC. Additionally, the review accentuates the encouraging outcomes of particle therapy in enhancing local control and survival rates, minimizing treatment-related toxicity, and advocating for continued research and clinical trials. In conclusion, the integration of RT into multimodal HCC treatment strategies, coupled with the emergence of particle therapy, is crucial for advancing oncologic management, emphasizing the need for relentless innovation and personalized treatment approaches.
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Citations
Citations to this article as recorded by
- Treatment of intermediate-to-advanced unresectable hepatocellular carcinoma is shifting toward a multidisciplinary strategy that includes multiple modalities as needed
Ken Sato
World Journal of Gastroenterology.2025;[Epub] CrossRef - Development and Validation of Monte Carlo Methods for Converay: A Proof-of-Concept Study
Rodolfo Figueroa, Francisco Malano, Alejandro Cuadra, Jaime Guarda, Jorge Leiva, Fernando Leyton, Adlin López, Claudio Solé, Mauro Valente
Cancers.2025; 17(7): 1189. CrossRef - A Comparative Analysis of the Roles of von Willebrand Factor and ADAMTS13 in Hepatocellular Carcinoma: A Bioinformatics and Microarray-Based Study
Durmuş Ayan, Şerife Buket Bozkurt Polat, Ergül Bayram, Esma Özmen, Fatma Esin Aydın, Serpil Ersan
Current Issues in Molecular Biology.2025; 47(4): 270. CrossRef - Evaluation of the LI-RADS radiation treatment response assessment v2024 in comparison with the modified RECIST
Hokun Kim, Bohyun Kim, Seok Hyun Son, Jeong Won Jang, Pil Soo Sung, Joon-Il Choi, Suho Kim, Jung Suk Oh, Ho Jong Chun
European Radiology.2025; 35(12): 7549. CrossRef - Primary small cell-like hepatocellular carcinoma arising in a patient with fatty liver disease without cirrhosis: a case report and literature review
Hyun Bin Choi, Jeong-Ju Yoo, Susie Chin, Sang Gyune Kim, Young-Seok Kim
Gastroenterology Report.2025;[Epub] CrossRef - Efficacy of Radiotherapy in Combination with Immune Checkpoint Blockade for Hepatocellular Carcinoma and Portal Vein Tumor Thrombosis
Yunjeong Lee, Minkyung Park, Eun Sun Jang, Gwanghyun Choi, Sook-Hyang Jeong, Jin Won Kim, Minsu Kang, Jee Hyun Kim, Changhoon Song, Kyubo Kim, Jin-Wook Kim
The Korean Journal of Medicine.2025; 100(5): 252. CrossRef
- Treatment of intermediate-to-advanced unresectable hepatocellular carcinoma is shifting toward a multidisciplinary strategy that includes multiple modalities as needed
Case Report
- Novel management of expected post-radiotherapy complications in hepatocellular carcinoma patients: a case report
- Sung Hoon Chang, Tae Suk Kim, Yong Hwan Jeon, Nuri Hyun Jung, Dae Hee Choi
- J Liver Cancer. 2022;22(2):183-187. Published online August 24, 2022
- DOI: https://doi.org/10.17998/jlc.2022.08.03
- 3,696 Views
- 67 Downloads
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Abstract
PDF
- In recent years, radiotherapy (RT) has been used to treat hepatocellular carcinoma (HCC) at each stage. This clinical trend has developed with the increasing improvement of RT techniques, which show clinical results comparable to those of other treatment modalities. Intensity-modulated radiotherapy uses a high radiation dose to improve treatment effectiveness. However, the associated radiation toxicity can damage adjacent organs. Radiation-induced gastric damage with gastric ulcers is a complication of RT. This report presents a novel management strategy for preventing post-RT gastric ulcers. We present the case of a 53-year-old male patient diagnosed with HCC, who experienced gastric ulcer after RT. Before the second round of RT, the patient was administered a gas-foaming agent, which was effective in preventing RT complications.
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