Journal of Liver Cancer

Review Article

Intrahepatic cholangiocarcinoma: histological diversity and the role of the pathologist: Mina Komuta; J Liver Cancer. 2024;24(1):17-22. Published online January 3, 2024; DOI: https://doi.org/10.17998/jlc.2023.12.11

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Intrahepatic cholangiocarcinoma (iCCA) is one of the primary liver cancers and presents with tumor heterogeneity. About 50% of iCCAs comprise actionable mutations, which completely change patient management. In addition, the precise diagnosis of iCCA, including subtype, has become crucial, and pathologists play an important role in this regard. This review focuses on iCCA heterogeneity; looking at different perspectives to guide diagnosis and optimal treatment choice.

Citations

Citations to this article as recorded by

Refinement of histologic subtypes and identification of biomarkers linked to unfavorable prognosis in cholangiocarcinoma: The ENSCCA registries’ framework for digital twin advancement
Guido Carpino, Diletta Overi, Rocio I.R. Macias, Vincenzo Cardinale, Laura Izquierdo-Sanchez, Pilar Acedo, Marco Rengo, Michail Doukas, Timothy J. Kendall, Julien Calderaro, Lara R. Heij, Konrad Reichel, Stefano Leone, Paolo Onori, Barbara Franceschini, C
Hepatology.2026; 83(4): 753. CrossRef
Surgical management of intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma: a narrative review of principles, technical nuances, and emerging strategies
Woohyung Lee, Kwang Pyo Hong, Jae Hoon Lee, Mirang Lee, Minkyu Sung, Seung Jae Lee, Ki Byung Song, Dae Wook Hwang, Song Cheol Kim
Journal of Liver Cancer.2026; 26(1): 19. CrossRef
Trends and Disparities in Intrahepatic Cholangiocarcinoma-related Mortality in the United States from 1999 to 2020
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Journal of Gastrointestinal Cancer.2025;[Epub] CrossRef
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Annals of Diagnostic Pathology.2025; 79: 152515. CrossRef
From barriers to solutions: an expert-based algorithm for cholangiocarcinoma and other biliary tract cancers testing in the Era of precision oncology
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Expert Review of Molecular Diagnostics.2025; 25(8): 495. CrossRef
Role of Radiation Therapy for Biliary Tract Cancers
Molly A. Chakraborty, Ritesh Kumar, Brett L. Ecker, Haejin In, Russell C. Langan, Mariam Eskander, Salma K. Jabbour
Current Oncology.2025; 32(10): 545. CrossRef
Imaging findings of intrahepatic cholangiocarcinoma for prognosis prediction and treatment decision-making: a narrative review
Jun Gu Kang, Taek Chung, Dong Kyu Kim, Hyungjin Rhee
The Ewha Medical Journal.2024;[Epub] CrossRef

Case Report

Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma: Allison Kaye L. Pagarigan, Paulo Giovanni L. Mendoza; J Liver Cancer. 2023;23(1):219-224. Published online March 13, 2023; DOI: https://doi.org/10.17998/jlc.2023.02.24

3,963 Views
88 Downloads
4 Citations

Abstract PDF

Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatric cases reported in literature. Recounted is a case of a 49-year-old female who presented with acute right upper quadrant abdominal pain, elevated serum alpha fetoprotein and a large liver mass on imaging. Hepatectomy was performed under clinical suspicion of hepatocellular carcinoma. Immunomorphologic characteristics of the tumor proved consistent with hepatoblastoma of mixed epithelial and mesenchymal type. Hepatocellular carcinoma remains to be the primary differential diagnosis for adult hepatoblastoma, however, distinguishing between these two neoplasms requires close histomorphologic assessment and immunohistochemical profiling as clinical, radiologic and gross pathologic findings typically overlap. Making this distinction is highly crucial in the timely initiation of surgical and chemotherapeutic interventions for this inherently aggressive and rapidly fatal disease.

Citations

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Yanting Zhang, Xuedi Yu, Junjie Ge, Jingjing Wang, Chuanfeng Bai, Suyi Kang, Jingfu Wang
Frontiers in Pediatrics.2026;[Epub] CrossRef
Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care Center
Divya Achutha Ail, Malini Eapen, Pavithran Keechilat, Sudheendran Surendran, Naveen Viswanath
Indian Journal of Medical and Paediatric Oncology.2025; 46(06): 565. CrossRef
Blastomas of the digestive system in adults: A review
Yu Liu, Tony El Jabbour, Jonathan Somma, Yukihiro Nakanishi, Saverio Ligato, Hwajeong Lee, Zhi-Yan Fu
World Journal of Gastrointestinal Surgery.2024; 16(4): 1030. CrossRef
Adult Hepatoblastoma and Concomitant Hepatitis B Infection
Alejandro Nieto Dominguez, Sarah Elizabeth Eichinger, Elza Matrova, Anas Almoghrabi
ACG Case Reports Journal.2024; 11(9): e01491. CrossRef

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