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JLC : Journal of Liver Cancer

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Review Article
Intrahepatic cholangiocarcinoma: histological diversity and the role of the pathologist
Mina Komuta
J Liver Cancer. 2024;24(1):17-22.   Published online January 3, 2024
DOI: https://doi.org/10.17998/jlc.2023.12.11
  • 1,681 Views
  • 135 Downloads
AbstractAbstract PDF
Intrahepatic cholangiocarcinoma (iCCA) is one of the primary liver cancers and presents with tumor heterogeneity. About 50% of iCCAs comprise actionable mutations, which completely change patient management. In addition, the precise diagnosis of iCCA, including subtype, has become crucial, and pathologists play an important role in this regard. This review focuses on iCCA heterogeneity; looking at different perspectives to guide diagnosis and optimal treatment choice.
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Case Report
Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma
Allison Kaye L. Pagarigan, Paulo Giovanni L. Mendoza
J Liver Cancer. 2023;23(1):219-224.   Published online March 13, 2023
DOI: https://doi.org/10.17998/jlc.2023.02.24
  • 1,054 Views
  • 55 Downloads
  • 1 Citation
AbstractAbstract PDF
Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatric cases reported in literature. Recounted is a case of a 49-year-old female who presented with acute right upper quadrant abdominal pain, elevated serum alpha fetoprotein and a large liver mass on imaging. Hepatectomy was performed under clinical suspicion of hepatocellular carcinoma. Immunomorphologic characteristics of the tumor proved consistent with hepatoblastoma of mixed epithelial and mesenchymal type. Hepatocellular carcinoma remains to be the primary differential diagnosis for adult hepatoblastoma, however, distinguishing between these two neoplasms requires close histomorphologic assessment and immunohistochemical profiling as clinical, radiologic and gross pathologic findings typically overlap. Making this distinction is highly crucial in the timely initiation of surgical and chemotherapeutic interventions for this inherently aggressive and rapidly fatal disease.

Citations

Citations to this article as recorded by  
  • Blastomas of the digestive system in adults: A review
    Yu Liu, Tony El Jabbour, Jonathan Somma, Yukihiro Nakanishi, Saverio Ligato, Hwajeong Lee, Zhi-Yan Fu
    World Journal of Gastrointestinal Surgery.2024; 16(4): 1030.     CrossRef
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JLC : Journal of Liver Cancer