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Review Article
- Intrahepatic cholangiocarcinoma: histological diversity and the role of the pathologist
- Mina Komuta
- J Liver Cancer. 2024;24(1):17-22. Published online January 3, 2024
- DOI: https://doi.org/10.17998/jlc.2023.12.11
- 2,952 Views
- 205 Downloads
- 1 Citation
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Abstract
PDF - Intrahepatic cholangiocarcinoma (iCCA) is one of the primary liver cancers and presents with tumor heterogeneity. About 50% of iCCAs comprise actionable mutations, which completely change patient management. In addition, the precise diagnosis of iCCA, including subtype, has become crucial, and pathologists play an important role in this regard. This review focuses on iCCA heterogeneity; looking at different perspectives to guide diagnosis and optimal treatment choice.
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Citations
Citations to this article as recorded by
- Imaging findings of intrahepatic cholangiocarcinoma for prognosis
prediction and treatment decision-making: a narrative review
Jun Gu Kang, Taek Chung, Dong Kyu Kim, Hyungjin Rhee
The Ewha Medical Journal.2024;[Epub] CrossRef
- Imaging findings of intrahepatic cholangiocarcinoma for prognosis
prediction and treatment decision-making: a narrative review
Case Report
- Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma
- Allison Kaye L. Pagarigan, Paulo Giovanni L. Mendoza
- J Liver Cancer. 2023;23(1):219-224. Published online March 13, 2023
- DOI: https://doi.org/10.17998/jlc.2023.02.24
- 1,408 Views
- 63 Downloads
- 2 Citations
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Abstract
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- Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatric cases reported in literature. Recounted is a case of a 49-year-old female who presented with acute right upper quadrant abdominal pain, elevated serum alpha fetoprotein and a large liver mass on imaging. Hepatectomy was performed under clinical suspicion of hepatocellular carcinoma. Immunomorphologic characteristics of the tumor proved consistent with hepatoblastoma of mixed epithelial and mesenchymal type. Hepatocellular carcinoma remains to be the primary differential diagnosis for adult hepatoblastoma, however, distinguishing between these two neoplasms requires close histomorphologic assessment and immunohistochemical profiling as clinical, radiologic and gross pathologic findings typically overlap. Making this distinction is highly crucial in the timely initiation of surgical and chemotherapeutic interventions for this inherently aggressive and rapidly fatal disease.
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Citations
Citations to this article as recorded by- Blastomas of the digestive system in adults: A review
Yu Liu, Tony El Jabbour, Jonathan Somma, Yukihiro Nakanishi, Saverio Ligato, Hwajeong Lee, Zhi-Yan Fu
World Journal of Gastrointestinal Surgery.2024; 16(4): 1030. CrossRef - Adult Hepatoblastoma and Concomitant Hepatitis B Infection
Alejandro Nieto Dominguez, Sarah Elizabeth Eichinger, Elza Matrova, Anas Almoghrabi
ACG Case Reports Journal.2024; 11(9): e01491. CrossRef
- Blastomas of the digestive system in adults: A review
Review Article
- Recent updates on the classification of hepatoblastoma according to the International Pediatric Liver Tumors Consensus
- Se Un Jeong, Hyo Jeong Kang
- J Liver Cancer. 2022;22(1):23-29. Published online March 17, 2022
- DOI: https://doi.org/10.17998/jlc.2022.02.24
- 8,070 Views
- 594 Downloads
- 6 Citations
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Abstract
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- Hepatoblastoma is the most common pediatric liver malignancy and usually occurs within the first 3 years of life. In recent years, the overall incidence of hepatoblastoma has exhibited the greatest increase among all pediatric malignancies worldwide. The diagnosis of hepatoblastoma may be challenging due to the lack of a current consensus classification system. The International Pediatric Liver Tumors Consensus introduced guidelines and a consensus classification for the diagnosis of hepatoblastoma as either epithelial or mixed epithelial and mesenchymal and in the updated 5th edition of the World Health Organization Classification of Digestive System Tumors.
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Citations
Citations to this article as recorded by- Tumor‐associated macrophages: The key player in hepatoblastoma microenvironment and the promising therapeutic target
Ahmad Adawy, Yoshihiro Komohara, Taizo Hibi
Microbiology and Immunology.2024; 68(8): 249. CrossRef - Hepatoblastoma: A Case Report
Abel Ning Caballero, Kandecy Archer-Austin
Asploro Journal of Biomedical and Clinical Case Reports.2024; 7(3): 226. CrossRef - Adult Hepatoblastoma and Concomitant Hepatitis B Infection
Alejandro Nieto Dominguez, Sarah Elizabeth Eichinger, Elza Matrova, Anas Almoghrabi
ACG Case Reports Journal.2024; 11(9): e01491. CrossRef - Metabolic and Epigenetic Mechanisms in Hepatoblastoma: Insights into Tumor Biology and Therapeutic Targets
Yuanji Fu, Raquel Francés, Claudia Monge, Christophe Desterke, Agnès Marchio, Pascal Pineau, Yunhua Chang-Marchand, Jorge Mata-Garrido
Genes.2024; 15(11): 1358. CrossRef - Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma
Allison Kaye L. Pagarigan, Paulo Giovanni L. Mendoza
Journal of Liver Cancer.2023; 23(1): 219. CrossRef - Advances in Histological and Molecular Classification of Hepatocellular Carcinoma
Joon Hyuk Choi, Swan N. Thung
Biomedicines.2023; 11(9): 2582. CrossRef
- Tumor‐associated macrophages: The key player in hepatoblastoma microenvironment and the promising therapeutic target
Case Report
- Primary multifocal cystic signet ring neuroendocrine tumor of liver: a case report
- Nalini Bansal, Brahmananda Satapathy
- J Liver Cancer. 2021;21(2):187-193. Published online September 30, 2021
- DOI: https://doi.org/10.17998/jlc.2021.09.17
- 3,933 Views
- 80 Downloads
- 2 Citations
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Abstract
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- Primary signet ring neuroendocrine tumors of the liver are extremely rare tumors. Morphologically, they mimic signet ring cell adenocarcinomas; however, the absence of mucin by special stains and the expression of neuroendocrine markers help to diagnose these tumors. We herein report a case of a 47-year-old female who presented with multiple solid and cystic lesions in both liver lobes, which were initially suggested to be biliary cystadenocarcinoma on imaging. Liver biopsy of the lesion revealed the presence of a signet ring neoplasm with diffuse expression of synaptophysin and pan-cytokeratin. The case was subsequently diagnosed as a primary hepatic signet ring neuroendocrine tumor. The patient was offered 3 cycles of chemotherapy and is well preserved after 14 months of diagnosis. Although this is an extremely rare entity, its possibility should be considered in the differential diagnosis of neoplasms characterized by signet ring cell morphology.
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Citations
Citations to this article as recorded by- Gastric Neuroendocrine Tumor With Cystic Hepatic Metastases Mimicking Hepatic Echinococcosis: A Case Report
Rahul Gupta, Deepak Gusain, Nalini Bansal, Rahul Varshney, Arvind Singh
Cureus.2024;[Epub] CrossRef - HER-2-positive primary neuroendocrine neoplasms of the breast with signet ring feature: A case report and review of literature
Yunjin Li, Yi Cao, Xiaoying Wu, Ruijie Liu, Kuansong Wang
Frontiers in Oncology.2022;[Epub] CrossRef
- Gastric Neuroendocrine Tumor With Cystic Hepatic Metastases Mimicking Hepatic Echinococcosis: A Case Report
Review Article
- Histopathological Variants of Hepatocellular Carcinomas: an Update According to the 5th Edition of the WHO Classification of Digestive System Tumors
- Haeryoung Kim, Mi Jang, Young Nyun Park
- J Liver Cancer. 2020;20(1):17-24. Published online March 31, 2020
- DOI: https://doi.org/10.17998/jlc.20.1.17
- 16,369 Views
- 1,092 Downloads
- 34 Citations
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Abstract
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- Hepatocellular carcinoma (HCC) is heterogeneous in pathogenesis, phenotype and biological behavior. Various histopathological features of HCC had been sporadically described, and with the identification of common molecular alterations of HCC and its genomic landscape over the last decade, morpho-molecular correlation of HCC has become possible. As a result, up to 35% of HCCs can now be classified into histopathological variants, many of which have unique molecular characteristics. This review will provide an introduction to the variously described histopathological variants of HCC in the updated WHO Classification of Digestive System Tumors.
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Citations
Citations to this article as recorded by- Computational pathology: A survey review and the way forward
Mahdi S. Hosseini, Babak Ehteshami Bejnordi, Vincent Quoc-Huy Trinh, Lyndon Chan, Danial Hasan, Xingwen Li, Stephen Yang, Taehyo Kim, Haochen Zhang, Theodore Wu, Kajanan Chinniah, Sina Maghsoudlou, Ryan Zhang, Jiadai Zhu, Samir Khaki, Andrei Buin, Fatemeh
Journal of Pathology Informatics.2024; 15: 100357. CrossRef - Characterization of lymphocyte‐rich hepatocellular carcinoma and the prognostic role of tertiary lymphoid structures
Bokyung Ahn, Hee‐Sung Ahn, Jinho Shin, Eunsung Jun, Eun‐Young Koh, Yeon‐Mi Ryu, Sang‐Yeob Kim, Chang Ohk Sung, Ju Hyun Shim, JeongYeon Hong, Kyunggon Kim, Hyo Jeong Kang
Liver International.2024; 44(5): 1202. CrossRef - Clinical‐Radiologic Morphology‐Radiomics Model on Gadobenate Dimeglumine‐Enhanced MRI for Identification of Highly Aggressive Hepatocellular Carcinoma: Temporal Validation and Multiscanner Validation
Wanjing Zheng, Xiaodan Chen, Meilian Xiong, Yu Zhang, Yang Song, Dairong Cao
Journal of Magnetic Resonance Imaging.2024; 60(6): 2643. CrossRef - Diagnostic Model for Proliferative HCC Using LI‐RADS: Assessing Therapeutic Outcomes in Hepatectomy and TKI‐ICI Combination
Mengtian Lu, Zuyi Yan, Qi Qu, Guodong Zhu, Lei Xu, Maotong Liu, Jifeng Jiang, Chunyan Gu, Ying Chen, Tao Zhang, Xueqin Zhang
Journal of Magnetic Resonance Imaging.2024;[Epub] CrossRef - A Post-International Gastrointestinal Cancers’ Conference (IGICC) Position Statements
Suayib Yalcin, Sahin Lacin, Ahmed Kaseb, Bora Peynircioğlu, Murat Cantasdemir, Barbaros Çil, Pervin Hurmuz, Ahmet Doğrul, Murat Bozkurt, Hüseyin Abali, Okan Akhan, Halis Şimşek, Berksoy Sahin, Faruk Aykan, İdris Yücel, Gürkan Tellioğlu, Fatih Selçukbirici
Journal of Hepatocellular Carcinoma.2024; Volume 11: 953. CrossRef - The impact of matrix stiffness on hepatic cell function, liver fibrosis, and hepatocellular carcinoma—Based on quantitative data
Kiyoon Min, Sathish Kumar Karuppannan, Giyoong Tae
Biophysics Reviews.2024;[Epub] CrossRef - Gadoxetic Acid-Enhanced MRI-Based Radiomic Models for Preoperative Risk Prediction and Prognostic Assessment of Proliferative HCC
Zuyi Yan, Zixin Liu, Guodong Zhu, Mengtian Lu, Jiyun Zhang, Maotong Liu, Jifeng Jiang, Chunyan Gu, Xiaomeng Wu, Tao Zhang, Xueqin Zhang
Academic Radiology.2024;[Epub] CrossRef - CT-based radiomics nomogram to predict proliferative hepatocellular carcinoma and explore the tumor microenvironment
Gongzheng Wang, Feier Ding, Kaige Chen, Zhuoshuai Liang, Pengxi Han, Linxiang Wang, Fengyun Cui, Qiang Zhu, Zhaoping Cheng, Xingzhi Chen, Chencui Huang, Hongxia Cheng, Ximing Wang, Xinya Zhao
Journal of Translational Medicine.2024;[Epub] CrossRef - Exploring the role of liver resection as a first-line treatment option for multinodular BCLC-A hepatocellular carcinoma
Joo Hyun Oh, Dong Hyun Sinn
Journal of Liver Cancer.2024; 24(2): 126. CrossRef - Multifaceted Aspects of Dysfunctional Myelopoiesis in Cancer and Therapeutic Perspectives with Focus on HCC
Andrea Arleo, Annapaola Montagner, Catia Giovannini, Fabrizia Suzzi, Fabio Piscaglia, Laura Gramantieri
Biomolecules.2024; 14(12): 1496. CrossRef - Low-Baseline PD1+ Granulocytes Predict Responses to Atezolizumab–Bevacizumab in Hepatocellular Carcinoma
Catia Giovannini, Fabrizia Suzzi, Francesco Tovoli, Mariangela Bruccoleri, Mariarosaria Marseglia, Eleonora Alimenti, Francesca Fornari, Massimo Iavarone, Fabio Piscaglia, Laura Gramantieri
Cancers.2023; 15(6): 1661. CrossRef - Non-alcoholic fatty liver disease: the pathologist’s perspective
Wei-Qiang Leow, Anthony Wing-Hung Chan, Paulo Giovanni L. Mendoza, Regina Lo, Kihan Yap, Haeryoung Kim
Clinical and Molecular Hepatology.2023; 29(Suppl): S302. CrossRef - 2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma
Journal of Liver Cancer.2023; 23(1): 1. CrossRef - Three-dimensional multifrequency magnetic resonance elastography improves preoperative assessment of proliferative hepatocellular carcinoma
Guixue Liu, Di Ma, Huafeng Wang, Jiahao Zhou, Zhehan Shen, Yuchen Yang, Yongjun Chen, Ingolf Sack, Jing Guo, Ruokun Li, Fuhua Yan
Insights into Imaging.2023;[Epub] CrossRef - Lymphocyte-Rich Hepatocellular Carcinoma with Multiple Lymphadenopathy and Positive Epstein–Barr Virus Encoding Region
Pin-Yi Wang, Yu-Hsuan Kuo, Ming-Jen Sheu, Hsing-Tao Kuo, Wen-Ying Lee, Yu-Ting Kuo, Su-Hung Wang, Zu-Yau Lin
Case Reports in Hepatology.2023; 2023: 1. CrossRef - Genome-Wide Extrachromosomal Circular DNA Profiling of Paired Hepatocellular Carcinoma and Adjacent Liver Tissues
Jianyu Ye, Peixin Huang, Kewei Ma, Zixin Zhao, Ting Hua, Wenjing Zai, Jieliang Chen, Xiutao Fu
Cancers.2023; 15(22): 5309. CrossRef - Proliferative hepatocellular carcinomas in cirrhosis: patient outcomes of LI-RADS category 4/5 and category M
Subin Heo, Hyo Jeong Kang, Sang Hyun Choi, Sehee Kim, Youngeun Yoo, Won-Mook Choi, So Yeon Kim, Seung Soo Lee
European Radiology.2023; 34(5): 2974. CrossRef - ФИБРОЛАМЕЛЛЯРНАЯ ГЕПАТОЦЕЛЛЮЛЯРНАЯ КАРЦИНОМА
М.Т. Orucov, E.T. Şamdancı, Ə.B. Həsənov
Azerbaijan Medical Journal.2023; (3): 172. CrossRef - Cellular heterogeneity and plasticity in liver cancer
Lo-Kong Chan, Yu-Man Tsui, Daniel Wai-Hung Ho, Irene Oi-Lin Ng
Seminars in Cancer Biology.2022; 82: 134. CrossRef - MRI features of histologic subtypes of hepatocellular carcinoma: correlation with histologic, genetic, and molecular biologic classification
Ja Kyung Yoon, Jin-Young Choi, Hyungjin Rhee, Young Nyun Park
European Radiology.2022; 32(8): 5119. CrossRef - Variant Hepatocellular Carcinoma Subtypes According to the 2019 WHO Classification: An Imaging-Focused Review
Liang Meng Loy, Hsien Min Low, Jin-Young Choi, Hyungjin Rhee, Chin Fong Wong, Cher Heng Tan
American Journal of Roentgenology.2022; 219(2): 212. CrossRef - Paraneoplastic syndromes in hepatocellular carcinoma: a review
Yuki Ong, Cheong Wei Terence Huey, Vishalkumar Girishchandra Shelat
Expert Review of Gastroenterology & Hepatology.2022; 16(5): 449. CrossRef - Morphomolecular Classification Update on Hepatocellular Adenoma, Hepatocellular Carcinoma, and Intrahepatic Cholangiocarcinoma
Venkata S. Katabathina, Lokesh Khanna, Venkateswar R. Surabhi, Marta Minervini, Krishna Shanbhogue, Anil K. Dasyam, Srinivasa R. Prasad
RadioGraphics.2022; 42(5): 1338. CrossRef - 2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma
Clinical and Molecular Hepatology.2022; 28(4): 583. CrossRef - 2022 KLCA-NCC Korea Practice Guidelines for the Management of Hepatocellular Carcinoma
Korean Journal of Radiology.2022; 23(12): 1126. CrossRef - Histomorphological Subtypes of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: Review and Update
Yoon Jung Hwang, Haeryoung Kim
AJSP: Reviews and Reports.2022; 27(6): 234. CrossRef - Pediatric Primary Hepatic Tumors: Diagnostic Considerations
Bryony Lucas, Sanjita Ravishankar, Irina Pateva
Diagnostics.2021; 11(2): 333. CrossRef - A Case of Lymphocyte-Rich Hepatocellular Carcinoma in a Patient Who Was Treated for Colon Cancer
Jae Won Song, Ho Soo Chun, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Young Nyun Park, Dai Hoon Han, Do Young Kim
Journal of Liver Cancer.2021; 21(1): 69. CrossRef - HCC You Cannot See
Vaishnavi Boppana, Sakshi Sahni, Joseph Glass, Christopher Chang, Denis M McCarthy
Digestive Diseases and Sciences.2021; 66(7): 2185. CrossRef - An update on subtypes of hepatocellular carcinoma: From morphology to molecular
Monika Vyas, Dhanpat Jain
Indian Journal of Pathology and Microbiology.2021; 64(5): 112. CrossRef - HCC: role of pre- and post-treatment tumor biology in driving adverse outcomes and rare responses to therapy
Sandeep Arora, Roberta Catania, Amir Borhani, Natally Horvat, Kathryn Fowler, Carla Harmath
Abdominal Radiology.2021; 46(8): 3686. CrossRef - Gadoxetate-enhanced MRI Features of Proliferative Hepatocellular Carcinoma Are Prognostic after Surgery
Hyo-Jin Kang, Haeryoung Kim, Dong Ho Lee, Bo Yun Hur, Yoon Jung Hwang, Kyung-Suk Suh, Joon Koo Han
Radiology.2021; 300(3): 572. CrossRef - Radiologic Diagnosis of Hepatocellular Carcinoma
Woo Kyoung Jeong
The Korean Journal of Gastroenterology.2021; 78(5): 261. CrossRef - Update on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpoint
Nese Karadag Soylu
Journal of Gastrointestinal Cancer.2020; 51(4): 1176. CrossRef
- Computational pathology: A survey review and the way forward
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