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Review Article
Intrahepatic cholangiocarcinoma: histological diversity and the role of the pathologist
Mina Komuta
J Liver Cancer. 2024;24(1):17-22.   Published online January 3, 2024
DOI: https://doi.org/10.17998/jlc.2023.12.11
  • 1,681 Views
  • 135 Downloads
AbstractAbstract PDF
Intrahepatic cholangiocarcinoma (iCCA) is one of the primary liver cancers and presents with tumor heterogeneity. About 50% of iCCAs comprise actionable mutations, which completely change patient management. In addition, the precise diagnosis of iCCA, including subtype, has become crucial, and pathologists play an important role in this regard. This review focuses on iCCA heterogeneity; looking at different perspectives to guide diagnosis and optimal treatment choice.
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Case Report
Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma
Allison Kaye L. Pagarigan, Paulo Giovanni L. Mendoza
J Liver Cancer. 2023;23(1):219-224.   Published online March 13, 2023
DOI: https://doi.org/10.17998/jlc.2023.02.24
  • 1,054 Views
  • 55 Downloads
  • 1 Citation
AbstractAbstract PDF
Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatric cases reported in literature. Recounted is a case of a 49-year-old female who presented with acute right upper quadrant abdominal pain, elevated serum alpha fetoprotein and a large liver mass on imaging. Hepatectomy was performed under clinical suspicion of hepatocellular carcinoma. Immunomorphologic characteristics of the tumor proved consistent with hepatoblastoma of mixed epithelial and mesenchymal type. Hepatocellular carcinoma remains to be the primary differential diagnosis for adult hepatoblastoma, however, distinguishing between these two neoplasms requires close histomorphologic assessment and immunohistochemical profiling as clinical, radiologic and gross pathologic findings typically overlap. Making this distinction is highly crucial in the timely initiation of surgical and chemotherapeutic interventions for this inherently aggressive and rapidly fatal disease.

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  • Blastomas of the digestive system in adults: A review
    Yu Liu, Tony El Jabbour, Jonathan Somma, Yukihiro Nakanishi, Saverio Ligato, Hwajeong Lee, Zhi-Yan Fu
    World Journal of Gastrointestinal Surgery.2024; 16(4): 1030.     CrossRef
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Review Article
Recent updates on the classification of hepatoblastoma according to the International Pediatric Liver Tumors Consensus
Se Un Jeong, Hyo Jeong Kang
J Liver Cancer. 2022;22(1):23-29.   Published online March 17, 2022
DOI: https://doi.org/10.17998/jlc.2022.02.24
  • 6,578 Views
  • 522 Downloads
  • 3 Citations
AbstractAbstract PDF
Hepatoblastoma is the most common pediatric liver malignancy and usually occurs within the first 3 years of life. In recent years, the overall incidence of hepatoblastoma has exhibited the greatest increase among all pediatric malignancies worldwide. The diagnosis of hepatoblastoma may be challenging due to the lack of a current consensus classification system. The International Pediatric Liver Tumors Consensus introduced guidelines and a consensus classification for the diagnosis of hepatoblastoma as either epithelial or mixed epithelial and mesenchymal and in the updated 5th edition of the World Health Organization Classification of Digestive System Tumors.

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Citations to this article as recorded by  
  • Tumor‐associated macrophages: The key player in hepatoblastoma microenvironment and the promising therapeutic target
    Ahmad Adawy, Yoshihiro Komohara, Taizo Hibi
    Microbiology and Immunology.2024;[Epub]     CrossRef
  • Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma
    Allison Kaye L. Pagarigan, Paulo Giovanni L. Mendoza
    Journal of Liver Cancer.2023; 23(1): 219.     CrossRef
  • Advances in Histological and Molecular Classification of Hepatocellular Carcinoma
    Joon Hyuk Choi, Swan N. Thung
    Biomedicines.2023; 11(9): 2582.     CrossRef
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Case Report
Primary multifocal cystic signet ring neuroendocrine tumor of liver: a case report
Nalini Bansal, Brahmananda Satapathy
J Liver Cancer. 2021;21(2):187-193.   Published online September 30, 2021
DOI: https://doi.org/10.17998/jlc.2021.09.17
  • 3,454 Views
  • 78 Downloads
  • 2 Citations
AbstractAbstract PDF
Primary signet ring neuroendocrine tumors of the liver are extremely rare tumors. Morphologically, they mimic signet ring cell adenocarcinomas; however, the absence of mucin by special stains and the expression of neuroendocrine markers help to diagnose these tumors. We herein report a case of a 47-year-old female who presented with multiple solid and cystic lesions in both liver lobes, which were initially suggested to be biliary cystadenocarcinoma on imaging. Liver biopsy of the lesion revealed the presence of a signet ring neoplasm with diffuse expression of synaptophysin and pan-cytokeratin. The case was subsequently diagnosed as a primary hepatic signet ring neuroendocrine tumor. The patient was offered 3 cycles of chemotherapy and is well preserved after 14 months of diagnosis. Although this is an extremely rare entity, its possibility should be considered in the differential diagnosis of neoplasms characterized by signet ring cell morphology.

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  • Gastric Neuroendocrine Tumor With Cystic Hepatic Metastases Mimicking Hepatic Echinococcosis: A Case Report
    Rahul Gupta, Deepak Gusain, Nalini Bansal, Rahul Varshney, Arvind Singh
    Cureus.2024;[Epub]     CrossRef
  • HER-2-positive primary neuroendocrine neoplasms of the breast with signet ring feature: A case report and review of literature
    Yunjin Li, Yi Cao, Xiaoying Wu, Ruijie Liu, Kuansong Wang
    Frontiers in Oncology.2022;[Epub]     CrossRef
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Review Article
Histopathological Variants of Hepatocellular Carcinomas: an Update According to the 5th Edition of the WHO Classification of Digestive System Tumors
Haeryoung Kim, Mi Jang, Young Nyun Park
J Liver Cancer. 2020;20(1):17-24.   Published online March 31, 2020
DOI: https://doi.org/10.17998/jlc.20.1.17
  • 15,102 Views
  • 1,042 Downloads
  • 29 Citations
AbstractAbstract PDF
Hepatocellular carcinoma (HCC) is heterogeneous in pathogenesis, phenotype and biological behavior. Various histopathological features of HCC had been sporadically described, and with the identification of common molecular alterations of HCC and its genomic landscape over the last decade, morpho-molecular correlation of HCC has become possible. As a result, up to 35% of HCCs can now be classified into histopathological variants, many of which have unique molecular characteristics. This review will provide an introduction to the variously described histopathological variants of HCC in the updated WHO Classification of Digestive System Tumors.

Citations

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  • Computational Pathology: A Survey Review and The Way Forward
    Mahdi S. Hosseini, Babak Ehteshami Bejnordi, Vincent Quoc-Huy Trinh, Lyndon Chan, Danial Hasan, Xingwen Li, Stephen Yang, Taehyo Kim, Haochen Zhang, Theodore Wu, Kajanan Chinniah, Sina Maghsoudlou, Ryan Zhang, Jiadai Zhu, Samir Khaki, Andrei Buin, Fatemeh
    Journal of Pathology Informatics.2024; : 100357.     CrossRef
  • Characterization of lymphocyte‐rich hepatocellular carcinoma and the prognostic role of tertiary lymphoid structures
    Bokyung Ahn, Hee‐Sung Ahn, Jinho Shin, Eunsung Jun, Eun‐Young Koh, Yeon‐Mi Ryu, Sang‐Yeob Kim, Chang Ohk Sung, Ju Hyun Shim, JeongYeon Hong, Kyunggon Kim, Hyo Jeong Kang
    Liver International.2024; 44(5): 1202.     CrossRef
  • Clinical‐Radiologic Morphology‐Radiomics Model on Gadobenate Dimeglumine‐Enhanced MRI for Identification of Highly Aggressive Hepatocellular Carcinoma: Temporal Validation and Multiscanner Validation
    Wanjing Zheng, Xiaodan Chen, Meilian Xiong, Yu Zhang, Yang Song, Dairong Cao
    Journal of Magnetic Resonance Imaging.2024;[Epub]     CrossRef
  • Diagnostic Model for Proliferative HCC Using LI‐RADS: Assessing Therapeutic Outcomes in Hepatectomy and TKI‐ICI Combination
    Mengtian Lu, Zuyi Yan, Qi Qu, Guodong Zhu, Lei Xu, Maotong Liu, Jifeng Jiang, Chunyan Gu, Ying Chen, Tao Zhang, Xueqin Zhang
    Journal of Magnetic Resonance Imaging.2024;[Epub]     CrossRef
  • A Post-International Gastrointestinal Cancers’ Conference (IGICC) Position Statements
    Suayib Yalcin, Sahin Lacin, Ahmed Kaseb, Bora Peynircioğlu, Murat Cantasdemir, Barbaros Çil, Pervin Hurmuz, Ahmet Doğrul, Murat Bozkurt, Hüseyin Abali, Okan Akhan, Halis Şimşek, Berksoy Sahin, Faruk Aykan, İdris Yücel, Gürkan Tellioğlu, Fatih Selçukbirici
    Journal of Hepatocellular Carcinoma.2024; Volume 11: 953.     CrossRef
  • The impact of matrix stiffness on hepatic cell function, liver fibrosis, and hepatocellular carcinoma—Based on quantitative data
    Kiyoon Min, Sathish Kumar Karuppannan, Giyoong Tae
    Biophysics Reviews.2024;[Epub]     CrossRef
  • Low-Baseline PD1+ Granulocytes Predict Responses to Atezolizumab–Bevacizumab in Hepatocellular Carcinoma
    Catia Giovannini, Fabrizia Suzzi, Francesco Tovoli, Mariangela Bruccoleri, Mariarosaria Marseglia, Eleonora Alimenti, Francesca Fornari, Massimo Iavarone, Fabio Piscaglia, Laura Gramantieri
    Cancers.2023; 15(6): 1661.     CrossRef
  • Non-alcoholic fatty liver disease: the pathologist’s perspective
    Wei-Qiang Leow, Anthony Wing-Hung Chan, Paulo Giovanni L. Mendoza, Regina Lo, Kihan Yap, Haeryoung Kim
    Clinical and Molecular Hepatology.2023; 29(Suppl): S302.     CrossRef
  • 2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma

    Journal of Liver Cancer.2023; 23(1): 1.     CrossRef
  • Three-dimensional multifrequency magnetic resonance elastography improves preoperative assessment of proliferative hepatocellular carcinoma
    Guixue Liu, Di Ma, Huafeng Wang, Jiahao Zhou, Zhehan Shen, Yuchen Yang, Yongjun Chen, Ingolf Sack, Jing Guo, Ruokun Li, Fuhua Yan
    Insights into Imaging.2023;[Epub]     CrossRef
  • Lymphocyte-Rich Hepatocellular Carcinoma with Multiple Lymphadenopathy and Positive Epstein–Barr Virus Encoding Region
    Pin-Yi Wang, Yu-Hsuan Kuo, Ming-Jen Sheu, Hsing-Tao Kuo, Wen-Ying Lee, Yu-Ting Kuo, Su-Hung Wang, Zu-Yau Lin
    Case Reports in Hepatology.2023; 2023: 1.     CrossRef
  • Genome-Wide Extrachromosomal Circular DNA Profiling of Paired Hepatocellular Carcinoma and Adjacent Liver Tissues
    Jianyu Ye, Peixin Huang, Kewei Ma, Zixin Zhao, Ting Hua, Wenjing Zai, Jieliang Chen, Xiutao Fu
    Cancers.2023; 15(22): 5309.     CrossRef
  • Proliferative hepatocellular carcinomas in cirrhosis: patient outcomes of LI-RADS category 4/5 and category M
    Subin Heo, Hyo Jeong Kang, Sang Hyun Choi, Sehee Kim, Youngeun Yoo, Won-Mook Choi, So Yeon Kim, Seung Soo Lee
    European Radiology.2023; 34(5): 2974.     CrossRef
  • Cellular heterogeneity and plasticity in liver cancer
    Lo-Kong Chan, Yu-Man Tsui, Daniel Wai-Hung Ho, Irene Oi-Lin Ng
    Seminars in Cancer Biology.2022; 82: 134.     CrossRef
  • MRI features of histologic subtypes of hepatocellular carcinoma: correlation with histologic, genetic, and molecular biologic classification
    Ja Kyung Yoon, Jin-Young Choi, Hyungjin Rhee, Young Nyun Park
    European Radiology.2022; 32(8): 5119.     CrossRef
  • Variant Hepatocellular Carcinoma Subtypes According to the 2019 WHO Classification: An Imaging-Focused Review
    Liang Meng Loy, Hsien Min Low, Jin-Young Choi, Hyungjin Rhee, Chin Fong Wong, Cher Heng Tan
    American Journal of Roentgenology.2022; 219(2): 212.     CrossRef
  • Paraneoplastic syndromes in hepatocellular carcinoma: a review
    Yuki Ong, Cheong Wei Terence Huey, Vishalkumar Girishchandra Shelat
    Expert Review of Gastroenterology & Hepatology.2022; 16(5): 449.     CrossRef
  • Morphomolecular Classification Update on Hepatocellular Adenoma, Hepatocellular Carcinoma, and Intrahepatic Cholangiocarcinoma
    Venkata S. Katabathina, Lokesh Khanna, Venkateswar R. Surabhi, Marta Minervini, Krishna Shanbhogue, Anil K. Dasyam, Srinivasa R. Prasad
    RadioGraphics.2022; 42(5): 1338.     CrossRef
  • 2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma

    Clinical and Molecular Hepatology.2022; 28(4): 583.     CrossRef
  • 2022 KLCA-NCC Korea Practice Guidelines for the Management of Hepatocellular Carcinoma

    Korean Journal of Radiology.2022; 23(12): 1126.     CrossRef
  • Histomorphological Subtypes of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: Review and Update
    Yoon Jung Hwang, Haeryoung Kim
    AJSP: Reviews and Reports.2022; 27(6): 234.     CrossRef
  • Pediatric Primary Hepatic Tumors: Diagnostic Considerations
    Bryony Lucas, Sanjita Ravishankar, Irina Pateva
    Diagnostics.2021; 11(2): 333.     CrossRef
  • A Case of Lymphocyte-Rich Hepatocellular Carcinoma in a Patient Who Was Treated for Colon Cancer
    Jae Won Song, Ho Soo Chun, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Young Nyun Park, Dai Hoon Han, Do Young Kim
    Journal of Liver Cancer.2021; 21(1): 69.     CrossRef
  • HCC You Cannot See
    Vaishnavi Boppana, Sakshi Sahni, Joseph Glass, Christopher Chang, Denis M McCarthy
    Digestive Diseases and Sciences.2021; 66(7): 2185.     CrossRef
  • An update on subtypes of hepatocellular carcinoma: From morphology to molecular
    Monika Vyas, Dhanpat Jain
    Indian Journal of Pathology and Microbiology.2021; 64(5): 112.     CrossRef
  • HCC: role of pre- and post-treatment tumor biology in driving adverse outcomes and rare responses to therapy
    Sandeep Arora, Roberta Catania, Amir Borhani, Natally Horvat, Kathryn Fowler, Carla Harmath
    Abdominal Radiology.2021; 46(8): 3686.     CrossRef
  • Gadoxetate-enhanced MRI Features of Proliferative Hepatocellular Carcinoma Are Prognostic after Surgery
    Hyo-Jin Kang, Haeryoung Kim, Dong Ho Lee, Bo Yun Hur, Yoon Jung Hwang, Kyung-Suk Suh, Joon Koo Han
    Radiology.2021; 300(3): 572.     CrossRef
  • Radiologic Diagnosis of Hepatocellular Carcinoma
    Woo Kyoung Jeong
    The Korean Journal of Gastroenterology.2021; 78(5): 261.     CrossRef
  • Update on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpoint
    Nese Karadag Soylu
    Journal of Gastrointestinal Cancer.2020; 51(4): 1176.     CrossRef
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JLC : Journal of Liver Cancer