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THE KOREAN LIVER CANCER ASSOCIATION
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- Prognostic Significance of Preoperative Controlling Nutritional Status Score in Patients Who Underwent Hepatic Resection for Hepatocellular Carcinoma
- Bum-Soo Kim
- J Liver Cancer. 2020;20(2):106-112. Published online September 30, 2020
- DOI: https://doi.org/10.17998/jlc.20.2.106
- 3,851 Views
- 89 Downloads
- 1 Citation
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Abstract
PDF - Malnutrition is common in patients with hepatocellualar carcinoma (HCC), and is associated with postoperative complications after hepatectomy, and also increased mortality. However, there is currently no recommendation for assessment of nutritional status in HCC patients. The controlling nutritional status (CONUT) score has been correlated with prognosis in gastrointestinal cancer patients, but there are few reports on the prognostic significance of the CONUT score in patients who underwent hepatectomy for HCC. Existing results show that patients with high CONUT scores who undergo hepatectomy for HCC have poorer survival outcomes, and experience more complications than other patients. In this paper, we review the literature, and reveal that patients who underwent hepatectomy for HCC with high preoperative CONUT scores had poorer outcomes than those with low CONUT scores. Therefore, we conclude that a preoperative CONUT score may be useful for prognostic prediction in patients with HCC undergoing curative hepatectomy.
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Citations
Citations to this article as recorded by
- Demographic, clinical and psychological predictors of malnutrition among people with liver cancer
Yumi Kim, Sung Reul Kim, Kyounghae Kim, Su Jong Yu
European Journal of Oncology Nursing.2024; 68: 102497. CrossRef
- Demographic, clinical and psychological predictors of malnutrition among people with liver cancer
- Nutrition and Management of Hepatic Encephalopathy
- Jin-Woo Lee
- Journal of the Korean Liver Cancer Study Group. 2012;12(2):120-127. Published online September 30, 2012
- 1,024 Views
- 37 Downloads
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Abstract
PDF
- It has been estimated that at least 25% of patients with liver cirrhosis experience hepatic encephalopathy during the natural history of the disease. Hepatic encephalopathy is more frequent in patients with more severe liver disease. Also, malnutrition is common in patients with liver cirrhosis, and is considered a significant prognostic factor affecting quality of life, outcome, and survival. Inadequate intake of nutrients, the hypermetabolic state, the diminished synthetic capacity of the liver and the impaired absorption of nutrients are themain reasons that disrupt the metabolic balance in cirrhosis. In the general approach to cirrhotic patients, the initial and most important step for the clinician is to recognize the extent of malnutrition. Unfortunately, the Child-Pugh-Turcotte classification and the model for end-stage liver disease (MELD) do not include an assessment of nutritional status in spite of the fact that malnutrition plays an important role in morbidity and mortality in end-stage liver failure. To date, the practice of dietary protein restriction for patients with liver cirrhosis is deeply embedded among medical practitioners and dietitians. However, the negative effects of protein restriction are clear, that is, increased protein catabolism, the release of amino acids from the muscle, and possible worsening of hepatic encephalopathy. Nutritional support with sufficient protein requirements, antioxidants, vitamins as well as probiotics may improve nutritional status, liver function, and hepatic encephalopathy in patients with liver cirrhosis.
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