Journal of Liver Cancer

Case Reports

Nivolumab for Advanced Hepatocellular Carcinoma with Multiple Lung Metastases after Sorafenib Failure: Jaewoong Kim, Jin Won Chang, Jun Yong Park; J Liver Cancer. 2020;20(1):72-77. Published online March 31, 2020; DOI: https://doi.org/10.17998/jlc.20.1.72

5,398 Views
147 Downloads
1 Citation

Over the past decade, standard first-line systemic treatment of advanced hepatocellular carcinoma (HCC) has been based on sorafenib, a multi-kinase inhibitor. Regorafenib, another tyrosine kinase inhibitor, is the only second-line therapy that has been globally approved after progression under sorafenib treatment. Recently, immunotherapeutic agents have emerged as promising treatment options in many different malignancies, including advanced HCC. Nivolumab is the first immunotherapy approved by the Food and Drug Administration for use in HCC patients with advanced-stage second-line after sorafenib failure. In this report, a case of advanced HCC with multiple lung metastases in which a complete response and maintained progression-free status was achieved with nivolumab, following the failure of transarterial chemoembolization and sorafenib is presented. We hope this report may help expand the clinical application of second-line treatment.

Citations

Citations to this article as recorded by

Infiltrative hepatocellular carcinoma with multiple lung metastasis completely cured using nivolumab: a case report
Ji Eun Han, Hyo Jung Cho, Soon Sun Kim, Jae Youn Cheong
Journal of Liver Cancer.2021; 21(2): 169. CrossRef

Spontaneous Regression of Recurred Hepatocellular Carcinoma with Multiple Lung Metastases: Beom Yong Yoon, Heon Young Lee, Se Woong Hwang, Se Young Park, Hye Jin Kim, Hye Won Jang,, Byung Seok Lee; J Liver Cancer. 2015;15(1):46-51. Published online March 31, 2015; DOI: https://doi.org/10.17998/jlc.15.1.46

1,122 Views
9 Downloads

Abstract PDF: Hepatocellular carcinoma (HCC) is the most common form of liver malignancy. Spontaneous regression of HCC is extremely rare phenomenon and mechanism of regression remains obscure. 75-year-old woman previously diagnosed with hepatitis C virus-related liver cirrhosis was found to have single mass in liver with elevation of α-fetoprotein level to 10,320 ng/mL. Transarterial chemoembolization (TACE) was performed. 27 months after TACE recurred HCC with multiple lung nodules were confirmed. The patient refused any therapeutic modality. The patient underwent follow-up without any anti-cancer treatment. 8 months after recurrence follow up computed tomography scan revealed spontaneous regression of HCC and completely disappeared lung nodules. The patient is currently doing well and without any evidence of recurrence. The causes of spontaneous regression of HCC are not well understood. Proposed mechanisms are ischemic injury, biological factors, herbal medicine, immunological variations. Further studies are necessary to improve our understanding of this rare phenomenon.

A Case of Successful Pulmonary Resection in Patient with Lung Metastasis of Hepatocellular Carcinoma: Ik Yoon, Hyung Joon Yim, Jin Nam Kim, Sun Min Park, Jeong Han Kim, Seung Hwa Lee, Ju-Han Lee, Hwan-Hoon Chung, Hong Sik Lee, Hyung Joo Park, Sang Woo Lee, Jai Hyun Choi; Journal of the Korean Liver Cancer Study Group. 2008;8(1):81-85. Published online June 30, 2008

610 Views
0 Download

Abstract PDF: Lung is the most common site of extrahepatic metastasis from hepatocellular carcinoma (HCC). Until now, there have been few reports about surgical resection for pulmonary metastasis from HCC, but the role and the indication of surgery for pulmonary metastasis remains unclear. We report a case of advanced HCC with pulmonary metastasis, which was effectively treated by metastasectomy. A 45-year-old male patient who had received TACE (transarterial chemoembolization) 14 times for hepatocellular carcinoma was found to have solitary metastasis in the right hilar area of the lung. Surgical metastasectomy was performed and pulmonary metastatic nodule was successfully removed. Primary tumor in the liver was effectively treated with TACE and follow-up CT (computed tomography) showed no viable tumor in the liver and the lung.

A Case of Complete Remission after Multiple Sessions of Local Treatment in Metastatic Hepatocellular Carcinoma: Tae Gun Moon, Joon Hyeok Lee, Moon Seok Choi, Kwang Cheol Koh, Jae J. Kim, Seung Woon Paik, Byung Cheol Yoo, Jong Chul Rhee; Journal of the Korean Liver Cancer Study Group. 2006;6(1):70-76. Published online June 30, 2006

648 Views
3 Downloads

Abstract PDF: With advances in the diagnosis and local treatement of HCC, which have resulted in a prolongation of survival, extrahepatic metastasis of HCC influence the survival of HCC patients. In particular, the frequency of death due to respiratory failure resulting from pulmonary metastases, pain and fractures resulting from bone metastases has been increased gradually. The efficacy of systemic treatment for the extrahepatic metastases is discouraging because of a lack of effective chemotherapeutic agents, reduced hepatic reserve and adverse effects. We report one
case
of the prolonged survival in a patient with hepatocellular carcinoma after treatment of bone and lung metastases.

A Case of Hepatocellular Carcinoma with Lung Metastasis Treated with Transarterial Chemoembolization: Gab Jin Cheon, Yun Soo Kim, Joon Seong Jung, Young Seok Kim, Jong Ho Moon, Young Deok Cho, Moon Sung Lee, Chan Sup Shim, Boo Sung Kim; Journal of the Korean Liver Cancer Study Group. 2001;1(1):122-126. Published online June 30, 2001

585 Views
2 Downloads

Abstract PDF: A 54 year-old male patient was transferred from pulmonologic division to evaluate hepatic mass incidentally found on chest CT scan. Thirteen years ago, he had been diagnosed as a hepatitis B virus carrier. HBs Ag was positive, and AFP was 118.09 ng/ml. On admission, Chest PA showed multiple variable sized nodular opacities in both lungs. Ill defined inhomogeneous enhanced mass was found at liver dome with multiple metastatic lesions on chest CT scan. Hepatic angiogram showed multiple, abnormal tumor staining on liver dome and nearly entire hepatic segments. After the 2nd TACE using mytomycin C, lipiodol and gelform, previously noted hematogeneous metastatic nodules in both lungs disappeared and volume of liver mass was decreased dramatically and AFP was normalized.

First
Prev
Page of 1
Next
Last

Search