Original Article
- Synergistic effects of L-arginine and argininosuccinate synthetase 1 in inducing apoptosis in hepatocellular carcinoma
-
Jin Sun Kim, Won-Mook Choi, Ha-Il Kim, Sung Won Chung, Jonggi Choi, Danbi Lee, Kang Mo Kim
-
Received October 9, 2024 Accepted December 27, 2024 Published online January 14, 2025
-
DOI: https://doi.org/10.17998/jlc.2024.12.27
[Accepted]
-
-
Abstract
PDF
- Background/Aims
Hepatocellular carcinoma (HCC) is a malignant cancer with an increasing incidence worldwide. Although numerous efforts have been made to identify effective therapies for HCC, current strategies have limitations. We present a new approach for targeting L-arginine and argininosuccinate synthetase 1 (ASS1).
Methods
ASS1 expression in HCC cell lines and primary hepatocytes was detected using PCR and western blotting. Proliferation, migration, signaling pathways, and nitric oxide production in HCC cell lines were measured using MTS, colony formation, wound healing, western blot, and Griess assays.
Results
ASS1 expression varied among the HCC cell lines, and cisplatin cytotoxicity was ASS1-dependent. L-arginine alone induced apoptosis in HCC cell lines, regardless of ASS1 expression; however, its effect was enhanced in ASS1-expressing HCC cell lines. Cisplatin cytotoxicity also increased, suggesting that L-arginine acts as a sensitizer to cisplatin in HCC cell lines. ASS1 and L-arginine produced nitric oxide and inhibited key proliferation- and survival-related signaling pathways such as PI3K/Akt and MAPK. Additionally, ASS1 and L-arginine reduced the expression of PKM1 and PKM2 in the glycolysis pathway.
Conclusions
Our study revealed that ASS1 and L-arginine exhibited anticancer effects in HCC and sensitized cisplatin-resistant HCC cells to chemotherapy. The combination of ASS1 and L-arginine significantly enhanced the anticancer effects, even in HCC cell lines with low or absent ASS1 expression. These findings highlight the critical roles of arginine and ASS1 in HCC and suggest that increasing arginine availability could be a promising therapeutic strategy.
Recommendation and Guideline
- Local ablation for hepatocellular carcinoma: 2024 expert consensus-based practical recommendation of the Korean Liver Cancer Association
-
Seungchul Han, Pil Soo Sung, Soo Young Park, Jin Woong Kim, Hyun Pyo Hong, Jung-Hee Yoon, Dong Jin Chung, Joon Ho Kwon, Sanghyeok Lim, Jae Hyun Kim, Seung Kak Shin, Tae Hyung Kim, Dong Ho Lee, Jong Young Choi
-
J Liver Cancer. 2024;24(2):131-144. Published online August 30, 2024
-
DOI: https://doi.org/10.17998/jlc.2024.08.04
-
-
2,028
Views
-
172
Downloads
-
1
Citation
-
Abstract
PDF
Supplementary Material
- Local ablation for hepatocellular carcinoma (HCC), a non-surgical option that directly targets and destroys tumor cells, has advanced significantly since the 1990s. Therapies with different energy sources, such as radiofrequency ablation, microwave ablation, and cryoablation, employ different mechanisms to induce tumor necrosis. The precision, safety, and effectiveness of these therapies have increased with advances in guiding technologies and device improvements. Consequently, local ablation has become the firstline treatment for early-stage HCC. The lack of organized evidence and expert opinions regarding patient selection, pre-procedure preparation, procedural methods, swift post-treatment evaluation, and follow-up has resulted in clinicians following varied practices. Therefore, an expert consensus-based practical recommendation for local ablation was developed by a group of experts in radiology and hepatology from the Research Committee of the Korean Liver Cancer Association in collaboration with the Korean Society of Image-guided Tumor Ablation to provide useful information and guidance for performing local ablation and for the pre- and posttreatment management of patients.
-
Citations
Citations to this article as recorded by

- Practical consensus multi-specialty guidelines on image-guided ablation for hepatocellular carcinoma
David S. Lu
Journal of Liver Cancer.2024; 24(2): 120. CrossRef
Original Article
- Outcomes of liver resection and transarterial chemoembolization in patients with multinodular BCLC-A hepatocellular carcinoma
-
Jiwon Yang, Won-Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Deok-Bog Moon, Dong-Hwan Jung, Jonggi Choi
-
J Liver Cancer. 2024;24(2):178-191. Published online April 3, 2024
-
DOI: https://doi.org/10.17998/jlc.2024.03.25
-
-
1,905
Views
-
113
Downloads
-
1
Citation
-
Abstract
PDF
Supplementary Material
- Backgrounds/Aims
This study aimed to compare the outcomes of liver resection (LR) and transarterial chemoembolization (TACE) in patients with multinodular hepatocellular carcinoma (HCC) within the Milan criteria who were not eligible for liver transplantation.
Methods
We retrospectively analyzed 483 patients with multinodular HCC within the Milan criteria, who underwent either LR or TACE as an initial therapy between 2013 and 2022. The overall survival (OS) in the entire population and recurrence-free survival (RFS) in patients who underwent LR and TACE and achieved a complete response were analyzed. Propensity score (PS) matching analysis was also used for a fair comparison of outcomes between the two groups.
Results
Among the 483 patients, 107 (22.2%) and 376 (77.8%) underwent LR and TACE, respectively. The median size of the largest tumor was 2.0 cm, and 72.3% of the patients had two HCC lesions. The median OS and RFS were significantly longer in the LR group than in the TACE group (P<0.01 for both). In the multivariate analysis, TACE (adjusted hazard ratio [aHR], 1.81 and aHR, 2.41) and large tumor size (aHR, 1.43 and aHR, 1.44) were significantly associated with worse OS and RFS, respectively. The PS-matched analysis also demonstrated that the LR group had significantly longer OS and RFS than the TACE group (PS<0.05).
Conclusions
In this study, LR showed better OS and RFS than TACE in patients with multinodular Barcelona Clinic Liver Cancer stage A HCC. Therefore, LR can be considered an effective treatment option for these patients.
-
Citations
Citations to this article as recorded by

- Exploring the role of liver resection as a first-line treatment option for multinodular BCLC-A hepatocellular carcinoma
Joo Hyun Oh, Dong Hyun Sinn
Journal of Liver Cancer.2024; 24(2): 126. CrossRef
Case Report
- Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma
-
Allison Kaye L. Pagarigan, Paulo Giovanni L. Mendoza
-
J Liver Cancer. 2023;23(1):219-224. Published online March 13, 2023
-
DOI: https://doi.org/10.17998/jlc.2023.02.24
-
-
1,615
Views
-
66
Downloads
-
2
Citations
-
Abstract
PDF
- Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatric cases reported in literature. Recounted is a case of a 49-year-old female who presented with acute right upper quadrant abdominal pain, elevated serum alpha fetoprotein and a large liver mass on imaging. Hepatectomy was performed under clinical suspicion of hepatocellular carcinoma. Immunomorphologic characteristics of the tumor proved consistent with hepatoblastoma of mixed epithelial and mesenchymal type. Hepatocellular carcinoma remains to be the primary differential diagnosis for adult hepatoblastoma, however, distinguishing between these two neoplasms requires close histomorphologic assessment and immunohistochemical profiling as clinical, radiologic and gross pathologic findings typically overlap. Making this distinction is highly crucial in the timely initiation of surgical and chemotherapeutic interventions for this inherently aggressive and rapidly fatal disease.
-
Citations
Citations to this article as recorded by

- Blastomas of the digestive system in adults: A review
Yu Liu, Tony El Jabbour, Jonathan Somma, Yukihiro Nakanishi, Saverio Ligato, Hwajeong Lee, Zhi-Yan Fu
World Journal of Gastrointestinal Surgery.2024; 16(4): 1030. CrossRef - Adult Hepatoblastoma and Concomitant Hepatitis B Infection
Alejandro Nieto Dominguez, Sarah Elizabeth Eichinger, Elza Matrova, Anas Almoghrabi
ACG Case Reports Journal.2024; 11(9): e01491. CrossRef
Review Article
- Non-alcoholic fatty liver disease-related hepatocellular carcinoma
-
Darine Daher, Karim Seif El Dahan, Amit G. Singal
-
J Liver Cancer. 2023;23(1):127-142. Published online February 9, 2023
-
DOI: https://doi.org/10.17998/jlc.2022.12.30
-
-
8,034
Views
-
300
Downloads
-
18
Citations
-
Abstract
PDF
- Non-alcoholic fatty liver disease (NAFLD), one of the most common causes of liver disease, is an increasingly common cause of hepatocellular carcinoma (HCC). Several demographic, clinical, and genetic factors contribute to HCC risk in NAFLD patients, which may inform risk stratification scores. Proven efficacious approaches to primary prevention approach in patients with non-viral liver disease remain an area of need. Semi-annual surveillance is associated with improved early tumor detection and reduced HCC-related mortality; however, patients with NAFLD have several challenges to effective surveillance, including under-recognition of at-risk patients, low surveillance utilization in clinical practice, and lower sensitivity of current tools for early-stage HCC detection. Treatment decisions are best made in a multidisciplinary fashion and are informed by several factors including tumor burden, liver dysfunction, performance status, and patient preferences. Although patients with NAFLD often have larger tumor burden and increased comorbidities compared to counterparts, they can achieve similar post-treatment survival with careful patient selection. Therefore, surgical therapies continue to provide a curative treatment option for patients diagnosed at an early stage. Although there has been debate about the efficacy of immune checkpoint inhibitors in patients with NAFLD, current data are insufficient to change treatment selection based on liver disease etiology.
-
Citations
Citations to this article as recorded by

- Coenzyme Q and Selenium Co-Supplementation Alleviate Methionine Choline-Deficient Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice
Hyewon Choi, Jiwon Choi, Yula Go, Jayong Chung
Nutrients.2025; 17(2): 229. CrossRef - Overnutrition and Lipotoxicity: Impaired Efferocytosis and Chronic Inflammation as Precursors to Multifaceted Disease Pathogenesis
Vivek Mann, Alamelu Sundaresan, Shishir Shishodia
Biology.2024; 13(4): 241. CrossRef - Risk of Hepatocellular Carcinoma by Steatotic Liver Disease and Its Newly Proposed Subclassification
Byeong Geun Song, Aryoung Kim, Myung Ji Goh, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Dong Hyun Sinn
Liver Cancer.2024; 13(5): 561. CrossRef - Risk of Bleeding in Hepatocellular Carcinoma Patients Treated with Atezolizumab/Bevacizumab: A Systematic Review and Meta-Analysis
Young-Gi Song, Kyeong-Min Yeom, Eun Ae Jung, Sang Gyune Kim, Young Seok Kim, Jeong-Ju Yoo
Liver Cancer.2024; : 1. CrossRef - Emerging role of exosomal microRNA in liver cancer in the era of precision medicine; potential and challenges
Tarek El Hayek, Osama Abdulwahab Alnaser-Almusa, Sulaiman Mamoun Alsalameh, Maya Taofik Alhalabi, Ahmad Nedal Sabbah, Eman Abdullah Alshehri, Tanveer Ahmad Mir, Naresh Kumar Mani, Khaled Al-Kattan, Raja Chinnappan, Ahmed Yaqinuddin
Frontiers in Molecular Biosciences.2024;[Epub] CrossRef - Trends in alcohol use and alcoholic liver disease in South Korea: a nationwide cohort study
Jeong-Ju Yoo, Dong Hyeon Lee, Young Chang, Hoongil Jo, Young Youn Cho, Sangheun Lee, Log Young Kim, Jae Young Jang
BMC Public Health.2024;[Epub] CrossRef - Surgical Implications for Nonalcoholic Steatohepatitis-Related Hepatocellular Carcinoma
Centura R. Anbarasu, Sophia Williams-Perez, Ernest R. Camp, Derek J. Erstad
Cancers.2024; 16(16): 2773. CrossRef - NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors
Nutan Sharma, Lakhwinder Singh, Aditya Sharma, Ajay Kumar, Dinesh Mahajan
Pharmacological Research.2024; 208: 107375. CrossRef - Biomarker Discovery in Liver Disease Using Untargeted Metabolomics in Plasma and Saliva
Noah J. Daniels, Courtney E. Hershberger, Matthew Kerosky, Chase J. Wehrle, Roma Raj, Nihal Aykun, Daniela S. Allende, Federico N. Aucejo, Daniel M. Rotroff
International Journal of Molecular Sciences.2024; 25(18): 10144. CrossRef - The histopathological and molecular heterogeneity of hepatocellular
carcinoma: a narrative review
Wonju Chung, Haeryoung Kim
The Ewha Medical Journal.2024;[Epub] CrossRef - Evolving epidemiology of non-alcoholic fatty liver disease in South Korea: incidence, prevalence, progression, and healthcare implications from 2010 to 2022
Jae Woo Park, Jeong-Ju Yoo, Dong Hyeon Lee, Young Chang, Hoongil Jo, Young Youn Cho, Sangheun Lee, Log Young Kim, Jae Young Jang
The Korean Journal of Internal Medicine.2024; 39(6): 931. CrossRef - The multifaceted anticancer potential of luteolin: involvement of NF-κB, AMPK/mTOR, PI3K/Akt, MAPK, and Wnt/β-catenin pathways
Deepika Singh, Gaurav Shukla
Inflammopharmacology.2024;[Epub] CrossRef - Ruptured hepatocellular carcinoma developed in a normal liver in a young patient with a body mass index of 33 kg/m2
Naoki Kirihata, Yoshiko Nakano, Koki Moriyoshi, Shin'ichi Miyamoto
BMJ Case Reports.2024; 17(12): e262841. CrossRef - Smoking Increases the Risk of Hepatocellular Carcinoma and Cardiovascular Disease in Patients with Metabolic-Associated Fatty Liver Disease
Jeong-Ju Yoo, Man Young Park, Eun Ju Cho, Su Jong Yu, Sang Gyune Kim, Yoon Jun Kim, Young Seok Kim, Jung-Hwan Yoon
Journal of Clinical Medicine.2023; 12(9): 3336. CrossRef - Reply: Validation of MELD 3.0 scoring system in East Asian patients with cirrhosis awaiting liver transplantation
Jeong-Ju Yoo, Sang Gyune Kim
Liver Transplantation.2023; 29(11): E38. CrossRef - Unraveling the Janus-Faced Role of Autophagy in Hepatocellular Carcinoma: Implications for Therapeutic Interventions
Thi Ha Nguyen, Tuan Minh Nguyen, Dinh Thi Minh Ngoc, Taesik You, Mi Kyung Park, Chang Hoon Lee
International Journal of Molecular Sciences.2023; 24(22): 16255. CrossRef - Comparative Analysis of Atezolizumab Plus Bevacizumab and Hepatic Artery Infusion Chemotherapy in Unresectable Hepatocellular Carcinoma: A Multicenter, Propensity Score Study
Ji Kim, Hee-Chul Nam, Chang-Wook Kim, Hee Cho, Jae-Sung Yoo, Ji Han, Jeong Jang, Jong Choi, Seung Yoon, Hyun Yang, Si Bae, Suho Kim, Jung Oh, Ho Chun, Chang Jeon, Jaegyoon Ahn, Pil Sung
Cancers.2023; 15(17): 4233. CrossRef - A nationwide study on the current treatment status and natural prognosis of hepatocellular carcinoma in elderly
Jeong-Ju Yoo, Jayoun Lee, Gi Hong Choi, Min Woo Lee, Dong Ah Park
Scientific Reports.2023;[Epub] CrossRef
Case Report
- Hepatocellular carcinoma diagnosed in a patient who had Fontan operation 30 years ago: a case report
-
Moon Haeng Hur, Haeryoung Kim, Jeong-Hoon Lee
-
J Liver Cancer. 2022;22(2):188-193. Published online August 31, 2022
-
DOI: https://doi.org/10.17998/jlc.2022.08.17
-
-
3,448
Views
-
80
Downloads
-
1
Citation
-
Abstract
PDF
- The Fontan operation is performed in patients with a single ventricle. As the systemic venous return is directly connected to the pulmonary circulation during this procedure, chronic hepatic congestion is induced, leading to Fontan-associated liver disease (FALD) including liver cirrhosis and hepatocellular carcinoma (HCC). In this report, we present a case of HCC diagnosed in a patient who underwent the Fontan operation 30 years ago. The patient underwent regular surveillance for FALD, which revealed a 4 cm-sized hepatic mass with elevated serum alpha-fetoprotein. After surgical treatment, there was no evidence of HCC recurrence during 3 years of follow-up. As the risk of HCC and Fontan-associated liver cirrhosis increases with the duration elapsed since the operation, regular surveillance should be emphasized. Serial follow-up of serum alpha-fetoprotein levels and abdominal imaging are necessary to achieve early and accurate diagnosis of HCC in post-Fontan patients.
-
Citations
Citations to this article as recorded by

- Surgical Treatment of Hepatocellular Carcinoma Arising from Fontan-associated Liver Disease: A Report of Three Cases
Koji Rinka, Kiyohide Kioka, Yuga Amano, Takashi Nakai, Yasuko Kawasaki, Yuki Kawasaki, Hisashi Sugiyama, Takeshi Inoue, Norifumi Kawada
Internal Medicine.2025;[Epub] CrossRef
Original Article
- The Feasibility Study of Contrast-enhanced Ultrasound Using a 3 Dimension Transducer for Tumor Volume Measurement in Rabbit Hepatic VX2 Carcinoma Comparison with 2 Dimension Ultrasound and 3 Dimension Ultrasound without Contrast: Preliminary Results
-
Kim, Jeehyun , Kim, Jung Hoon , Choi, Seo Youn , Han, Joon Koo
-
J Liver Cancer. 2018;18(1):23-32. Published online March 31, 2018
-
DOI: https://doi.org/10.17998/jlc.18.1.23
-
-
Abstract
PDF
- Background/Aims
To investigate the feasibility of tumor volume measurement using contrastenhanced ultrasound (US) with 3 dimension transducer (3D CEUS) in rabbit hepatic VX2 carcinoma.
Methods
Three different tumor volume measurements, including 2D US using the equation, 4/3(π)(abc), 3D US without contrast, and 3D CEUS were performed in 35 rabbit hepatic VX2 carcinomas. With the tumor volume from computerized tomography (CT) as a reference standard, we compared difference between CT volume and each different US tumor volume. The mean difference and correlation coefficient between each US volume measurement and CT volume were analyzed.
Results
Tumor volume measurement using 3D CEUS and 2D US using equation showed no statistical difference compared to CT volume (0.276 cm3, 0.212 cm3, and 0.263 cm3 vs. 0.306 cm3, 0.247 cm3, 0.276 cm3, P>0.05). However, 3D CEUS provided the highest correlation coefficient with CT volume (R=0.835 and 0.720) and the highest intraclass correlation (0.973 and 0.993). 3D CEUS provided a smaller mean difference with CT volume (0.016 cm3 and 0.033 cm3) than 2D US, showing 3D CEUS’s accurate measurement of tumor volume.
Conclusions
Due to its highly accurate, reliable, and reproducible measurements of tumor volume, 3D CEUS may be useful for predicting the therapeutic response evaluation after treatment.
Review Articles
- The General Rules for the Study of Primary Liver Cancer
-
Jae Young Jang, June Sung Lee, Hyung-Joon Kim, Jae-Jun Shim, Ji Hoon Kim, Bo Hyun Kim, Choon Hyuck Kwon, Seung Duk Lee, Hae Won Lee, Jung Hoon Kim, Woo Kyoung Jeong, Jin-Young Choi, Heung Kyu Ko, Dong Ho Lee, Haeryoung Kim, Baek-hui Kim, Sang Min Yoon, Soon Ho Um
-
J Liver Cancer. 2017;17(1):19-44. Published online March 31, 2017
-
DOI: https://doi.org/10.17998/jlc.17.1.19
-
-
3,240
Views
-
216
Downloads
-
31
Citations
-
Abstract
PDF
- The General Rules for the Study of Primary Liver Cancer was published in June 2001 as the first
edition. Since then, the 5th edition of the General Rules for the Study of Primary Liver Cancer
was published by the 17th Committee of the Korean Liver Cancer Association based on the
most recent data. The 5th edition of the General Rules for the Study of Primary Liver Cancer
ranged over numerous topics such as anatomy, medical assessment of the patients, staging
of hepatocellular carcinoma, description of the image findings, summary of hepatic resection,
description of the surgical specimens, liver transplantation, reporting the pathological findings,
pathological examinations of liver specimen, non-surgical treatment, radiotherapy, and
assessment of tumor response after non-surgical treatment of hepatocellular carcinoma. The 5th
General Rules for the Study of Primary Liver Cancer will not only become the basis of academic
development for liver cancer studies in Korea, but also serve as the primary form of national
liver cancer data accumulation based on standardized rules.
-
Citations
Citations to this article as recorded by

- Preoperative Prediction of Microvascular Invasion with Gadoxetic Acid-Enhanced Magnetic Resonance Imaging in Patients with Single Hepatocellular Carcinoma: The Implication of Surgical Decision on the Extent of Liver Resection
Na Reum Kim, Heejin Bae, Hyeo Seong Hwang, Dai Hoon Han, Kyung Sik Kim, Jin Sub Choi, Mi-Suk Park, Gi Hong Choi
Liver Cancer.2024; 13(2): 181. CrossRef - Radiologic Patterns Determine the Outcomes of Initial and Subsequent Transarterial Chemoembolization in Intermediate-Stage Hepatocellular Carcinoma
Ya-Wen Hung, I-Cheng Lee, Chen-Ta Chi, Rheun-Chuan Lee, Chien-An Liu, Nai-Chi Chiu, Hsuen-En Hwang, Yee Chao, Ming-Chih Hou, Yi-Hsiang Huang
Liver Cancer.2024; 13(1): 29. CrossRef - National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma
Faisal Saud Dar, Zaigham Abbas, Irfan Ahmed, Muhammad Atique, Usman Iqbal Aujla, Muhammad Azeemuddin, Zeba Aziz, Abu Bakar Hafeez Bhatti, Tariq Ali Bangash, Amna Subhan Butt, Osama Tariq Butt, Abdul Wahab Dogar, Javed Iqbal Farooqi, Faisal Hanif, Jahanzai
World Journal of Gastroenterology.2024; 30(9): 1018. CrossRef - Macroscopic Characterization of Hepatocellular Carcinoma: An Underexploited Source of Prognostic Factors
Stéphanie Gonvers, Sebastiao Martins-Filho, André Hirayama, Julien Calderaro, Rebecca Phillips, Emilie Uldry, Nicolas Demartines, Emmanuel Melloul, Young Nyun Park, Valérie Paradis, Swan Thung, Venancio Alves, Christine Sempoux, Ismail Labgaa
Journal of Hepatocellular Carcinoma.2024; Volume 11: 707. CrossRef - The impact of matrix stiffness on hepatic cell function, liver fibrosis, and hepatocellular carcinoma—Based on quantitative data
Kiyoon Min, Sathish Kumar Karuppannan, Giyoong Tae
Biophysics Reviews.2024;[Epub] CrossRef - Clinical Significance of Biliary Invasion at Diagnosis in Barcelona Clinic Liver Cancer Stage B–C Hepatocellular Carcinoma: A Nationwide Cohort Analysis in South Korea
Chai Hong Rim, Won Sup Yoon, Sunmin Park
Oncology.2024; : 1. CrossRef - Emerging role of natural bioactive compounds in navigating the future of liver disease
Neha Chaudhary, Muhammad Arif, Sheeba Shafi, Shom Prakash Kushwaha, Pushpendra Soni
iLIVER.2024; : 100140. CrossRef - Non-Invasive Imaging Biomarkers to Predict the Hepatopulmonary Shunt Fraction Before Transarterial Radioembolization in Patients with Hepatocellular Carcinoma
Charlie Alexander Hamm, Felix Busch, Anna Pöhlmann, Annabella Shewarega, Yubei He, Robin Schmidt, Han Xu, Gero Wieners, Bernhard Gebauer, Lynn Jeanette Savic
Journal of Hepatocellular Carcinoma.2023; Volume 10: 27. CrossRef - Histological subtypes of hepatocellular carcinoma: Their clinical and prognostic significance
So Hyun Shin, Joon Young Park, Chungsu Hwang, Hyun Jung Lee, Dong Hoon Shin, Jee Yeon Kim, Je Ho Ryu, Kwang Ho Yang, Tae Beom Lee, Jung Hee Lee
Annals of Diagnostic Pathology.2023; 64: 152134. CrossRef - Classification of microvascular invasion of hepatocellular carcinoma: correlation with prognosis and magnetic resonance imaging
Yoon Jung Hwang, Jae Seok Bae, Youngeun Lee, Bo Yun Hur, Dong Ho Lee, Haeryoung Kim
Clinical and Molecular Hepatology.2023; 29(3): 733. CrossRef - Microvascular Invasion in Hepatocellular Carcinoma: A Review of Its Definition, Clinical Significance, and Comprehensive Management
Zehao Zheng, Renguo Guan, Wang Jianxi, Zhen Zhao, Tianyi Peng, Chunsheng Liu, Ye Lin, Zhixiang Jian, Yuan Seng Wu
Journal of Oncology.2022; 2022: 1. CrossRef - A clinical and pathological update on hepatocellular carcinoma
Salvatore Lorenzo Renne, Luca Di Tommaso
Journal of Liver Cancer.2022; 22(1): 14. CrossRef - Comparing efficacies of different treatment regimens in patients with hepatocellular carcinoma accompanied by portal vein tumor thrombus using network meta-analysis
Seungji Lee, Sung Kyu Song, Byungje Bae, Yongkeun Park
Annals of Surgical Treatment and Research.2022; 103(5): 280. CrossRef - Post-TACE changes in ADC histogram predict overall and transplant-free survival in patients with well-defined HCC: a retrospective cohort with up to 10 years follow-up
Mohammadreza Shaghaghi, Mounes Aliyari Ghasabeh, Sanaz Ameli, Maryam Ghadimi, Bita Hazhirkarzar, Roya Rezvani Habibabadi, Pegah Khoshpouri, Ankur Pandey, Pallavi Pandey, Ihab R. Kamel
European Radiology.2021; 31(3): 1378. CrossRef - Risk Factors for Beyond Milan Recurrence After Hepatic Resection for Single Hepatocellular Carcinoma No Larger Than 5 Centimeters
Mina Kim, Taegyu Kim, Hyun Young Lee, Sung Yeon Hong, Hee‐Jung Wang, Bong‐Wan Kim
Liver Transplantation.2021; 27(8): 1116. CrossRef - Hepatocellular carcinoma: a clinical and pathological overview
Salvatore Lorenzo Renne, Samantha Sarcognato, Diana Sacchi, Maria Guido, Massimo Roncalli, Luigi Terracciano, Luca Di Tommaso
Pathologica.2021; 113(3): 203. CrossRef - Prognostic significance of viable tumor size measurement in hepatocellular carcinomas after preoperative locoregional treatment
Yoon Jung Hwang, Youngeun Lee, Hyunjin Park, Yangkyu Lee, Kyoungbun Lee, Haeryoung Kim
Journal of Pathology and Translational Medicine.2021; 55(5): 338. CrossRef - Response to Comment on “Subclassification of Microscopic Vascular Invasion in Hepatocellular Carcinoma”
Gi Hong Choi, Incheon Kang, Young Nyun Park
Annals of Surgery.2021; 274(6): e748. CrossRef - Subclassification of Microscopic Vascular Invasion in Hepatocellular Carcinoma
Incheon Kang, Mi Jang, Jae Geun Lee, Dai Hoon Han, Dong Jin Joo, Kyung Sik Kim, Myoung Soo Kim, Jin Sub Choi, Soon Il Kim, Young Nyun Park, Gi Hong Choi
Annals of Surgery.2021; 274(6): e1170. CrossRef - Up-to-date Knowledge on the Pathological Diagnosis of Hepatocellular Carcinoma
Ji Hae Nahm, Young Nyun Park
The Korean Journal of Gastroenterology.2021; 78(5): 268. CrossRef - Survival according to recurrence patterns after resection for transplantable hepatocellular carcinoma in HBV endemic area: Appraisal of liver transplantation strategy
Chung Gyo Seo, Sun Young Yim, Soon Ho Um, Yoo Ra Lee, Yoo Jin Lee, Tae Hyung Kim, Hyun Gil Goh, Young Sun Lee, Sang Jun Suh, Na Yeon Han, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Hyung Joon Yim, Ji Hoon Kim, Dong Sik Kim, Yoon Tae Jeen, Hoon
Clinics and Research in Hepatology and Gastroenterology.2020; 44(4): 532. CrossRef - Risk of Liver Cirrhosis and Hepatocellular Carcinoma after Fontan Operation: A Need for Surveillance
Jun Sik Yoon, Dong Ho Lee, Eun Ju Cho, Mi Kyoung Song, Young Hun Choi, Gi Beom Kim, Yun Bin Lee, Jeong-Hoon Lee, Su Jong Yu, Haeryoung Kim, Yoon Jun Kim, Jung-Hwan Yoon, Eun Jung Bae
Cancers.2020; 12(7): 1805. CrossRef - Update on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpoint
Nese Karadag Soylu
Journal of Gastrointestinal Cancer.2020; 51(4): 1176. CrossRef - How Should We Assign Large Infiltrative Hepatocellular Carcinomas for Staging?
Yoo Jin Lee, Yoo Ra Lee, Chung Gyo Seo, Hyun Gil Goh, Tae Hyung Kim, Sun Young Yim, Na Yeon Han, Jae Min Lee, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Hyonggin An, Beomjin Park, Yeon Seok Seo, Hyung Joon Yim, Ji Hoon Kim, Young Dong Yu, Dong Sik Kim, Yoon
Cancers.2020; 12(9): 2589. CrossRef - Substantial risk of recurrence even after 5 recurrence-free years in early-stage hepatocellular carcinoma patients
Jihye Kim, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
Clinical and Molecular Hepatology.2020; 26(4): 516. CrossRef - Role of tumor margin and ADC change in defining the need for additional treatments after the first TACE in patients with unresectable HCC
Mohammadreza Shaghaghi, Mounes AliyariG hasabeh, Sanaz Ameli, Maryam Ghadimi, Bita Hazhirkarzar, Roya Rezvani Habibabadi, Hao Tang, Pegah Khoshpouri, Qingxia Wu, Ankur Pandey, Pallavi Pandey, Azarakhsh Baghdadi, Ihab R. Kamel
European Journal of Radiology.2020; 133: 109389. CrossRef - The 7th/8th American Joint Committee on Cancer and the Modified Union for International Cancer Control Staging System for Hepatocellular Carcinoma
In-Gyu Kim, Xu-Guang Hu, Hee-Jung Wang, Bong-Wan Kim, Sung Yeon Hong, Xue-Yin Shen
Yonsei Medical Journal.2019; 60(2): 140. CrossRef - Hepatocellular carcinoma with extrahepatic metastasis: Are there still candidates for transarterial chemoembolization as an initial treatment?
Jihye Kim, Dong-Hyun Sinn, Moon Seok Choi, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Enzo Tagliazucchi
PLOS ONE.2019; 14(3): e0213547. CrossRef - Evaluation of early treatment response to radiotherapy for HCC using pre- and post-treatment MRI
So Hee Song, Woo Kyoung Jeong, Dongil Choi, Young Kon Kim, Hee Chul Park, Jeong Il Yu
Acta Radiologica.2019; 60(7): 826. CrossRef - The Clinicopathological and Prognostic Significance of the Gross Classification of Hepatocellular Carcinoma
Yangkyu Lee, Hyunjin Park, Hyejung Lee, Jai Young Cho, Yoo-Seok Yoon, Young-Rok Choi, Ho-Seong Han, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong, Soomin Ahn, Haeryoung Kim
Journal of Pathology and Translational Medicine.2018; 52(2): 85. CrossRef - Hepatobiliary MRI as novel selection criteria in liver transplantation for hepatocellular carcinoma
Ah Yeong Kim, Dong Hyun Sinn, Woo Kyoung Jeong, Young Kon Kim, Tae Wook Kang, Sang Yun Ha, Chul Keun Park, Gyu Seong Choi, Jong Man Kim, Choon Hyuck David Kwon, Jae-Won Joh, Min-Ji Kim, Insuk Sohn, Sin-Ho Jung, Seung Woon Paik, Won Jae Lee
Journal of Hepatology.2018; 68(6): 1144. CrossRef
- Animal Models of Liver Cancer: Current Status and Application in Preclinical Research
-
Hye-Lim Ju, Simon Weonsang Ro
-
J Liver Cancer. 2017;17(1):1-14. Published online March 31, 2017
-
DOI: https://doi.org/10.17998/jlc.17.1.1
-
-
3,613
Views
-
111
Downloads
-
Abstract
PDF
- Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. HCC develops
in various causes – Viral hepatitis infection, toxins, or other liver conditions - by activation of
oncogenes and/or inactivation of tumor suppressors. Understanding of signal pathways and
protein-protein interactions critical in tumor development may lead to novel treatment strategy.
To evaluate the progression of HCC and effects of potential therapies, various animal models
have been established. Experimental models of HCC provide valuable tools to investigate the
risk factors, new treatment modalities and biologic characteristics. Subcutaneous xenograft
models have been widely used in the past. However, with the advancement of in vivo imaging
technology, investigators are more concerned with the orthotopic models nowadays.
Genetically engineered mouse models have greatly facilitated studies of gene function in
HCC development. Lately, a novel approach for stable gene expression in mouse hepatocytes
by hydrodynamic injection has been developed. Each model has its own advantages and
disadvantages. Therefore, selecting the optimal models based on study objectives is necessary.
In this review, we highlight both the frequently used mouse models and some emerging ones
with emphasis on their merits or defects, and give advices for investigators to choose a ‘‘best-fit’’
animal model in HCC research.
- Evaluation of the Outcome after Transarterial Chemoembolization; Refinement of Barcelona Clinic Liver Cancer Stage-B from Eastern Point of View
-
Namiki Izumi
-
J Liver Cancer. 2016;16(1):7-11. Published online March 31, 2016
-
DOI: https://doi.org/10.17998/jlc.16.1.7
-
-
Abstract
PDF
- Transarterial chemoembolization (TACE) is recommended as the first line treatment option
for the patients with Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma
(HCC), however, treatment strategy and evaluation of effects after TACE has not been fully
established. Recently, sub-stage of BCLC stage B has been proposed and validated, but it
should be validated including a large number of the patients and its refinement should be
discussed. We have validated the sub-stage of BCLC stage B (B1-B4) by comparing overall
survival after TACE, and there was no statistically significant difference in overall survival
after TACE between B1 and B2. After excluding the patients with Child-Pugh point 7 from B1,
the overall survival was significantly better than that of B2. Therefore, up-to-seven criteria is
shown to be a reliable tool for the treatment strategy in the patients with intermediate stage
of HCC. Refinement of sub-stage of BCLC stage B has been proposed by some other institutes,
and it is important to establish novel treatment strategy for the patients with BCLC stage B
after TACE to improve the prognosis of the patients after TACE, and to define the best timing
for conversion to sorafenib or liver transplantation should be discussed. (J Liver Cancer
2016;16:7-11)
Original Article
- Subclassification of Hepatocellular Carcinoma with Barcelona Clinic Liver Cancer Intermediate Stage
-
Hye Won Lee, Seung Up Kim, Jun Yong Park, Do Young Kim, Snag Hoon Ahn, Kwang-Hyub Han, Beom Kyung Kim
-
J Liver Cancer. 2016;16(1):17-22. Published online March 31, 2016
-
DOI: https://doi.org/10.17998/jlc.16.1.17
-
-
Abstract
PDF
- Background/Aims
Hepatocellular carcinoma (HCC) with Barcelona Clinic Liver Cancer (BCLC)
intermediate stage includes a highly heterogeneous population. Here, we aimed to subclassify
hepatocellular carcinoma with BCLC intermediate stage for better prognostification.
Methods
Between 2003 and 2008, 325 patients who were newly diagnosed as HCC with
BCLC intermediate stage were considered eligible. Tumor factor and liver function were used
for sub-classification. Overall survival (OS) was analyzed using Kaplan-Meier method with a
comparison by log-rank test.
Results
A total of 325 patients with intermediate stage HCC were analyzed. Patients with
tumor size ≥7 cm, tumor number ≥4 and Child-Pugh class B had the worse OS compared
to those with tumor size <7 cm, tumor number <4 and Child-pugh class A, respectively (all
P<0.05). These three variables affected the OS independently from multivariate Cox regression
analysis (all P<0.05). So, using these three variables, patients were finally sub-classified as
those with fulfilling none of three factors (B-a), one of three factors (B-b), two of three factors
(B-c) and all of three factors (B-d) with the median OS of 39.2, 20.6, 12.0 and 8.3 months with
statistical significances (all P<0.05 between B-a and B-b, between B-b and B-c, and between
B-c and B-d), respectively.
Conclusions
Sub-classification of HCC with BCLC intermediate stage may be useful in not only
prognostification but also guidance of treatment strategies. (J Liver Cancer 2016;16:17-22)