Radiofrequency (RF) thermal ablation has been accepted as a promising technique for treating unresectable liver
tumors. However, any interventional procedure should only be performed with minimal morbidity and mortality.
Recently three separate multicenter surveys have shown an acceptable morbidity and mortality for a minimally
invasive technique. The mortality ranged from 0.1-0.5%, the major complication rate from 2.2-3.1% and minor
complication rate from 5-8.9%. The most common causes of death were sepsis and hepatic failure, and the most
common major complications were intra-peritoneal bleeding, hepatic abscess, bile duct injury, hepatic decompensation
and grounding pad burns. Minor complications and side effects were more common than major
complications, but most of them were transient and self-limiting. The operator must understand the broad
spectrum of complications after RF ablation as well as the strategies to minimize and manage appropriately