Hepatoid adenocarcinoma is a type of cancer with both adenocarcinomatous and
hepatocellular differentiation. Hepatoid adenocarcinoma has a typical character of high
serum alpha-fetoprotein (AFP) level. A 61-year-old female patient was admitted to the hospital
with abdominal pain and hepatic mass. Abdominal ultrasonography revealed a 20 cm sized
mass in liver. A huge hepatic mass looked like primary hepatocellular carcinoma (HCC) on
liver CT and MRI. Also, serum AFP was elevated to 24215.7 ng/mL. Right trisectionectomy was
done under the impression of HCC. However, the result of pathological findings including
immunohistochemical staining revealed that it was a hepatoid adenocarcinoma which was
originated from gallbladder