Journal of Liver Cancer

Well-differentiated Samll Hepatocellular Carcinoma, Early Hepatocellular Carcinoma and Dysplastic Nodule: Young Nyun Park; Journal of the Korean Liver Cancer Study Group. 2004;4(1):7-11. Published online June 30, 2004

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A Case of High-grade Dysplastic nodule Mimicking Well-differentiated Hepatocellular Carcinoma: Dong Hee Kim, Seung Woon Paik, Moon Seok Choi, Joon Hyuk Lee, Kwang Cheol Koh, Byung Cheol Yoo; Journal of the Korean Liver Cancer Study Group. 2004;4(1):42-45. Published online June 30, 2004

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Abstract PDF: The differential diagnosis of small nodular lesion arising in cirrhosis is basically restricted to early hepatocellular carcinoma(HCC) and non-malignant macronodules including large regenerative, low-and high-grade dysplastic nodules. Especially, differentiation of HCC from high-grade dysplasia is a well-recognized problem. Here we describe an unusual case of high-grade dysplasia which mimicks HCC. A 3 cm, hepatic mass was detected in a 47-year-old man with chronic hepatitis during abdominal sonography. Differential diagnosis was difficult with laboratory and radiological studies. It was proved to be a high-grade dysplasia after surgical resection.

Small Hepatocellular Carcinoma in Dysplastic Nodule: Chang Wook Kim, Eun Sun Jung, Jong Young Choi, Jeong Won Jang, Si Hyun Bae, Seung Kew Yoon, Chang Don Lee, Kyu Won Chung, Hee Sik Sun; Journal of the Korean Liver Cancer Study Group. 2004;4(1):50-54. Published online June 30, 2004

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Abstract PDF: Dysplastic nodule (DN) is considered as precancerous lesion of hepatocellular carcinoma (HCC). There are several evidences to support the theory about multistep progression of hepatocarcinogenesis. Recently we experienced a patient with HCC of the odule-in-nodule pattern, namely small HCC within DN, which supported the multistep theory of hepatocarcinogenesis. The tumor was seen as a 3 cm, arterial enhancing mass with delayed wash-out patterns in the segment Ⅶ at helical CT. The patient was treated by surgical resection. A 3.0×2.5 cm mass was seen in the resected specimen. A 2.2×1.5 cm, smaller nodule was observed within this mass, i.e. the odule-in-nodule pattern. Microscopically, various grades of HCC foci were seen within high grade DN. Because DN does not always progress to HCC, further studies are needed to evaluate what kind of DN has the high possibility of progressing of HCC at last.

Pathologic Differentiation between Dysplastic Nodule and Well-differentiated Heaptocellular Carcinoma: So-Young Jin; Journal of the Korean Liver Cancer Study Group. 2003;3(1):40-47. Published online July 31, 2003

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A Case of High Grade Dysplastic Nodule, Diagnosed as Hepatocelluar Carcinoma before Operation: Sang-Hyung Cho, Joong-Won Park, Hyun-Bae Son, Seong-Hoon Kim, Hyun-Jung Jang, Hong-Suk Park, Woo-Jin Lee, Sang-Jae Park, Eun-Kyung Hong, Chang-Min Kim; Journal of the Korean Liver Cancer Study Group. 2003;3(1):57-60. Published online July 31, 2003

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Abstract PDF: A 58-years-old male was referred to our hospital for further evaluation and treatment due to hepatic mass which was found on US. He was a heavy drinker and there was no evidence of abnormal finding in liver function test including HBs Ag and Anti-HCV Ab negative. Liver CT revealed an enhancing hepatic mass on arterial phase. we had confirmed hepatocellular carcinoma by sono-guided liver biopsy, and so performed left lobectomy. After operation, We diagnosed the resected liver specimen not hepatocellular carcinoma but high grade dysplastic nodule by several immunohistochemical staining. There was no evidence of recurrence during 5-month follow-up.

A Case of Hepatocellular Carcinoma Araising from Dysplastic Nodule: Sang Hoon Ahn, Yong Nyun Park, Yoon Jae Kim, Jae Yoon Chon, Young Myoung Moon, Kwang Hyub Han; Journal of the Korean Liver Cancer Study Group. 2003;3(1):83-86. Published online July 31, 2003

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Abstract PDF: Early diagnosis is invaluable for the treatment of hepatocellular carcinoma (HCC). However, it does not seem to be easy to differentiate between HCC arising in dysplastic nodule and dysplastic nodule without HCC foci by radiologic findings. We report a case of HCC arising in dysplastic nodule, which is confirmed by pathological examination of explanted liver.

Hypovascular Hepatocellular Carcinoma Supposed to Originate from Dysplastic Nodule: Nam Young Jo, Soon Ho Um, Kum Won Kim, Yun Hwan Kim, Nam Hee Won; Journal of the Korean Liver Cancer Study Group. 2003;3(1):87-91. Published online July 31, 2003

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Abstract PDF: Hepatocellular carcinoma (HCC) typically shows hepatic arterial phase contrast-enhancement and wash out pattern at portal phase. Hepatic dysplastic nodules show diverse imaging characteristics but commonly show hypoattenuation pattern at CT-imaging. We report an 3 cm sized atypical hypovascular HCC which was thought to orginate from dysplastic nodule. Fifty senven year old female who had suffered from chronic hepatitis B had three separate hepatic nodules initially. One in seg 7 diagnosed as well-differentiated HCC, another in seg 5 as dysplastic nodule by US guided needle biopsy. Remaining 1.5 cm sized nodule in seg 4 which showed isoattenuation at arterial phase and hypoattenuation at portal phase. We avoid invasive treatment to seg 4 nodule due to vicinity of great vessel. We performed transarterial chemoembolization (TACE) and percutaneous ethanol injection to the seg 7 & seg 5 lesions and followed up with TACE. At 2 years later the nodule in seg 4 grew up to 3 cm sized mass with showed persistency no arterial phase enhancement and partially hypoattenuating-isoattenuating pattern at portal phase. The mass diagnosed as clear cell type HCC (Edmoson grade Ⅱ) by US guided biopsy.

Pathologic Findings of Well Differentiated Hepatocellular Carcinoma: Eun Sil Yu; Journal of the Korean Liver Cancer Study Group. 2002;2(1):36-42. Published online July 31, 2002

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Radiologic Diagnosis of Dysplastic Nodule and Well-differentiated Hepatocellular Carcinoma: Pyo Nyun Kim; Journal of the Korean Liver Cancer Study Group. 2002;2(1):43-55. Published online July 31, 2002

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A Case of Well-differenciatied Hepatocellular Carcinoma in Dysplastic Nodule: Jeon-Ho Yang, Joong-Won Park, Hyun-Jung Jang, Hong-Suk Park, Sang-Jae Park, Eun Kyung Hong, Young-Soo Moon, Chang-Min Kim; Journal of the Korean Liver Cancer Study Group. 2002;2(1):96-100. Published online July 31, 2002

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Abstract PDF: A 35-year-old male patient was referred to our hospital, because a hepatic mass had been found on CT at another hospital. He was a heavy drinker, but he has never experienced any significant disease so far. Anti-HBs Ab, HBs Ag and anti-HCV Ab were negative. AFP level was normal. Triphasic liver CT scan revealed a 1.9 cm-sized, well-enhanced lesion at S6 on arterial phase. This lesion becomes isoattenuation on portal phase and slightly enhancing lesion on delayed phase. SPIO MRI scan reavealed a 1.9 cm-sized lesion with high signal intensity at S6 on T2WI. Precontrast ultrasonography revealed a enhancing nodule with mosaic pattern on S6 Contrast-enhanced ultrasonography revealed a centrally enhancing nodule early phase that showed washout on delayed phase. We had considered as the hepatocellular carcinoma. Segmentectomy of S6 for diagnosis and treatment was performed. We confirmed it to be well-differenciated hepatocellular carcinoma in dysplastic nodule. There was no evidence of recurrence during 9-month follow-up.

A Case of Early Hepatocellular Carcinoma with High Grade Dysplastic Nodule: Jae Young Jang , Yun Soo Kim, Young Kuk Cheon, Young Seok Kim, Jong Ho Moon, Young Deok Cho, So Young Jin, Chan Sup Shim, Boo Seong Kim; Journal of the Korean Liver Cancer Study Group. 2002;2(1):105-108. Published online July 31, 2002

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Abstract PDF: A 47-year-old male was referred for evaluation of a hepatic nodular lesion incidentally found on routine check up. He had no history of previous liver disease. Physical examination revealed no abonormality. Laboratory findings showed that HBsAG and anti-HCV were negative. Serum AST was minimally elevated and serum AFP was within normal range. Abdominal ultrasonogram showed a 1.3 cm-sized, hypoechoic nodule with peripheral halo in segment 5 of liver. Spiral CT revealed a well enhancing nodule in arterial phase, which could not be detected in portal and delayed phase. Liver biopsy showed well-differenciated hepatocellular carcinoma on the background of high grade dysplastic nodule. Surgical resection was recommended, however he refused and discharged.

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