Journal of Liver Cancer

Case Reports

Combined hepatocellular and cholangiocarcinoma: Jung Hyun Kwon, Si Hyun Bae, Jung Pil Suh, Ho Sung Park, Chan Ran You, Jong Young Choi, Seung Kew Yoon, Dong Hoon Lee, Ho Jong Chun, Byung Gil Choi, Chan Kwon Chung, Eun Sun Jung, Mi Ryung Ryu; Journal of the Korean Liver Cancer Study Group. 2007;7(1):49-54. Published online June 30, 2007

Abstract PDF: A 43 year-old-women patient was admitted for one month of jaundice. She was diagnosed hepatitis B carrier 17 years ago and has not done a routine check. Abdominal CT showed a large ill defined mass in left hepatic lobe with inhomogenous enhancement in arterial and delayed phase. The result of biopsy including the immunohistochemical stains showed the combined hepatocellular and cholangiocarcinoma (stage IVa, type C by Allen and Lisa). With the radiation therapy (3,910 cGy), six times of transarterial chemo-lipiodolization and two times of percutaneous ethanol injection, huge mass was markedly decreased in size and no stain in hepatic angiogram. She underwent left lobectomy.

A Case of Combined Hepatocellular-Cholangiocarcinoma Mimicking Focal Nodular Hyperplasia: Dong Hyun Shin, Kwang Cheol Koh, Geum Youn Gwak, Dong Il Choi, Cheol Keun Park, Moon Seok Choi, Joon Hyoek Lee, Seung Woon Paik, Byung Chul Yoo; Journal of the Korean Liver Cancer Study Group. 2007;7(1):55-58. Published online June 30, 2007

Abstract PDF: Combined hepatocellular and cholangiocarcinoma (cHCC-CC) is an uncommon form of primary liver cancer having features of both hepatocellular and billiary epithelial differentiation. We report a case of cHCC-CC in a patient who was serologically positive for hepatitis B virus. A 39-year-old male was diagnosed by ultrasonography with an asymptomatic tumor in the left lobe of the liver. Based on radiologic and serologic findings of elevated serum alpha-fetoprotein level, a preoperative diagnosis of hepatocellular carcinoma was made, but differential diagnosis included focal nodular hyperplasia, because tumor was enhanced in delayed phase in Godolinium MRI scan. A final diagnosis of cHCC-CC was made after operation.

A Case of Combined Hepatocellular and Cholangiocarcinoma: Woo Jin Chung, Sang Hun Jeon, Dong Choon Kim, Ju Yup Lee, Kyung In Lee, Hye Jin Seo, Byung Kuk Jang, Kyung Sik Park, Kwang Bum Cho, Jae Seok Hwang, Sung Hoon Ahn, Ku Jeong Kang, Young Hoon Kim, Jung Hyeok Kweon, Young Hwan Kim, Yu Na Kang; Journal of the Korean Liver Cancer Study Group. 2007;7(1):59-61. Published online June 30, 2007

Abstract PDF: A 51 years-old man who had postnecrotic liver cirrhosis due to chronic hepatitis B had elevated serum alpha fetoprotein level. According to computed tomographic findings, about 2.4cm sized mass was noted at segment 7 and he underwent segmentectomy. After 9 months later, multicentric recurrence was detected at segment 5-6, So, he underwent transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection therapy. After 22 months later, marginal recurrence was noted again at segment 6. So, he underwent 2nd TACE and he was following up over 30 months until now.

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