Journal of Liver Cancer

2 "Cholestasis"

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Case Reports

A Case of Hepatocellular Carcinoma with Bile Duct Invasion Treated with Transarterial Chemoembolization: Hee Yeon Kim, Chang Wook Kim, Chang Don Lee, Soo Lim Lee, Yoo Dong Won, Ye Il Kim; Journal of the Korean Liver Cancer Study Group. 2013;13(2):158-163. Published online September 30, 2013; DOI: https://doi.org/10.17998/jlc.13.2.158

Abstract PDF: A 53-year-old female patient visited our hospital complaining of intermittent right upper quadrant pain for 6 months. Computed tomography (CT) scan revealed an irregular shaped tumor at segment 4 of the liver with biliary tumor thrombi extending into the common bile duct. Percutaneous transhepatic biliary drainage was done for decompression of bile duct dilatation. The patient underwent 6 sessions of transarterial chemoembolization (TACE). Partial response was obtained shortly after TACE. However, regrowth of intraductal tumor resulted in an obstructive jaundice. After a slight decompression of the obstructive jaundice, the patient underwent TACE. Jaundice temporarily worsened following the TACE, but improved, and follow-up CT demonstrated some shrinkage of the intraductal mass. This case indicates that obstructive-type jaundice may not be a contraindication for TACE, and aggressive TACE may improve prognoses of patients with hepatocellular carcinoma and biliary tumor thrombi.

A Case of Hepatocellular Carcinoma with Bile Duct Invasion: Yeon Seok Seo, Beom Jin Park, Yun Hwan Kim, Soon Ho Um; Journal of the Korean Liver Cancer Study Group. 2008;8(1):69-73. Published online June 30, 2008

Abstract PDF: Cholestatic type hepatocellular carcinoma (HCC), in which obstructive jaundice is presented as the initial presentation of HCC, is rare. The prognosis of cholestatic type HCC is generally poor and most of the patients die from cholangitis or sepsis. Although some authors reported cases of successfully treated cholestatic type HCC with surgical resection, most of the patients are inoperable at the time of diagnosis. Several reports suggested that transarterial chemoembolization (TACE) showed a beneficial effect in improving the survival time and therefore, TACE should be tried as a first choice of therapy in patients with cholestatic HCC with sufficient liver reserve function. We experienced a case of obstructive jaundice as the initial presentation of HCC. His obstructive jaundice showed significant improvement after several sessions of TACE.

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